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On the illusion of auxotrophy: met15Δ yeast cells can grow on inorganic sulfur, thanks to the previously uncharacterized homocysteine synthase Yll058w.
Van Oss SB, Parikh SB, Castilho Coelho N, Wacholder A, Belashov I, Zdancewicz S, Michaca M, Xu J, Kang YP, Ward NP, Yoon SJ, McCourt KM, McKee J, Ideker T, VanDemark AP, DeNicola GM, Carvunis AR. Van Oss SB, et al. J Biol Chem. 2022 Dec;298(12):102697. doi: 10.1016/j.jbc.2022.102697. Epub 2022 Nov 13. J Biol Chem. 2022. PMID: 36379252 Free PMC article.
De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences.
Vakirlis N, Acar O, Hsu B, Castilho Coelho N, Van Oss SB, Wacholder A, Medetgul-Ernar K, Bowman RW 2nd, Hines CP, Iannotta J, Parikh SB, McLysaght A, Camacho CJ, O'Donnell AF, Ideker T, Carvunis AR. Vakirlis N, et al. Nat Commun. 2020 Feb 7;11(1):781. doi: 10.1038/s41467-020-14500-z. Nat Commun. 2020. PMID: 32034123 Free PMC article.
De novo gene birth.
Van Oss SB, Carvunis AR. Van Oss SB, et al. PLoS Genet. 2019 May 23;15(5):e1008160. doi: 10.1371/journal.pgen.1008160. eCollection 2019 May. PLoS Genet. 2019. PMID: 31120894 Free PMC article. No abstract available.
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