R01 CA139319/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2008	2
2009	3
2010	1
2011	3
2012	1
2013	5
2014	6
2015	3
2016	1
2017	5
2018	2
2019	2
2020	4
2021	2
2022	1
2024	0

1

Targeting ErbB3 and Cellular NADPH/NADP⁺ Abundance Sensitizes Cutaneous Melanomas to Ferroptosis Inducers.

Leu JI, Murphy ME, George DL. Leu JI, et al. ACS Chem Biol. 2022 May 20;17(5):1038-1044. doi: 10.1021/acschembio.2c00113. Epub 2022 Apr 14. ACS Chem Biol. 2022. PMID: 35420772 Free PMC article.

2

HSP70 inhibition blocks adaptive resistance and synergizes with MEK inhibition for the treatment of NRAS-mutant melanoma.

Parris JLD, Barnoud T, Leu JI, Leung JC, Ma W, Kirven NA, Poli ANR, Kossenkov AV, Liu Q, Salvino JM, George DL, Weeraratna AT, Chen Q, Murphy ME. Parris JLD, et al. Cancer Res Commun. 2021 Oct;1(1):17-29. doi: 10.1158/2767-9764.crc-21-0033. Cancer Res Commun. 2021. PMID: 35187538 Free PMC article.

3

P53 regulates cellular redox state, ferroptosis and metabolism.

Leu JI, Murphy ME, George DL. Leu JI, et al. Mol Cell Oncol. 2021 Feb 8;8(2):1877076. doi: 10.1080/23723556.2021.1877076. eCollection 2021. Mol Cell Oncol. 2021. PMID: 33860080 Free PMC article.

4

Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser.

Gnanapradeepan K, Leu JI, Basu S, Barnoud T, Good M, Lee JV, Quinn WJ, Kung CP, Ahima R, Baur JA, Wellen KE, Liu Q, Schug ZT, George DL, Murphy ME. Gnanapradeepan K, et al. Elife. 2020 Nov 10;9:e55994. doi: 10.7554/eLife.55994. Elife. 2020. PMID: 33170774 Free PMC article.

5

Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53.

Leu JI, Murphy ME, George DL. Leu JI, et al. Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26804-26811. doi: 10.1073/pnas.2009943117. Epub 2020 Oct 14. Proc Natl Acad Sci U S A. 2020. PMID: 33055209 Free PMC article.

6

A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors.

Barnoud T, Leung JC, Leu JI, Basu S, Poli ANR, Parris JLD, Indeglia A, Martynyuk T, Good M, Gnanapradeepan K, Sanseviero E, Moeller R, Tang HY, Cassel J, Kossenkov AV, Liu Q, Speicher DW, Gabrilovich DI, Salvino JM, George DL, Murphy ME. Barnoud T, et al. Cancer Res. 2020 Dec 1;80(23):5270-5281. doi: 10.1158/0008-5472.CAN-20-0397. Epub 2020 Oct 6. Cancer Res. 2020. PMID: 33023943 Free PMC article.

7

African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin.

Singh KS, Leu JI, Barnoud T, Vonteddu P, Gnanapradeepan K, Lin C, Liu Q, Barton JC, Kossenkov AV, George DL, Murphy ME, Dotiwala F. Singh KS, et al. Nat Commun. 2020 Jan 24;11(1):473. doi: 10.1038/s41467-019-14151-9. Nat Commun. 2020. PMID: 31980600 Free PMC article.

8

Fatty acid transport protein 2 reprograms neutrophils in cancer.

Veglia F, Tyurin VA, Blasi M, De Leo A, Kossenkov AV, Donthireddy L, To TKJ, Schug Z, Basu S, Wang F, Ricciotti E, DiRusso C, Murphy ME, Vonderheide RH, Lieberman PM, Mulligan C, Nam B, Hockstein N, Masters G, Guarino M, Lin C, Nefedova Y, Black P, Kagan VE, Gabrilovich DI. Veglia F, et al. Nature. 2019 May;569(7754):73-78. doi: 10.1038/s41586-019-1118-2. Epub 2019 Apr 17. Nature. 2019. PMID: 30996346 Free PMC article.

9

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53.

Leu JI, Murphy ME, George DL. Leu JI, et al. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8390-8396. doi: 10.1073/pnas.1821277116. Epub 2019 Apr 8. Proc Natl Acad Sci U S A. 2019. PMID: 30962386 Free PMC article.

10

Tailoring Chemotherapy for the African-Centric S47 Variant of TP53.

Barnoud T, Budina-Kolomets A, Basu S, Leu JI, Good M, Kung CP, Liu J, Liu Q, Villanueva J, Zhang R, George DL, Murphy ME. Barnoud T, et al. Cancer Res. 2018 Oct 1;78(19):5694-5705. doi: 10.1158/0008-5472.CAN-18-1327. Epub 2018 Aug 16. Cancer Res. 2018. PMID: 30115697 Free PMC article.

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