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Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.
Toikumo S, Jennings MV, Pham BK, Lee H, Mallard TT, Bianchi SB, Meredith JJ, Vilar-Ribó L, Xu H, Hatoum AS, Johnson EC, Pazdernik VK, Jinwala Z, Pakala SR, Leger BS, Niarchou M, Ehinmowo M; Penn Medicine BioBank; Jenkins GD, Batzler A, Pendegraft R, Palmer AA, Zhou H, Biernacka JM, Coombes BJ, Gelernter J, Xu K, Hancock DB, Cox NJ, Smoller JW, Davis LK, Justice AC, Kranzler HR, Kember RL, Sanchez-Roige S. Toikumo S, et al. Nat Hum Behav. 2024 Apr 17. doi: 10.1038/s41562-024-01851-6. Online ahead of print. Nat Hum Behav. 2024. PMID: 38632388
Epigenetic biomarkers for smoking cessation.
Fang F, Andersen AM, Philibert R, Hancock DB. Fang F, et al. Addict Neurosci. 2023 Jun;6:100079. doi: 10.1016/j.addicn.2023.100079. Epub 2023 Mar 1. Addict Neurosci. 2023. PMID: 37123087 Free PMC article.
Multi-ancestry meta-analysis of tobacco use disorder prioritizes novel candidate risk genes and reveals associations with numerous health outcomes.
Toikumo S, Jennings MV, Pham BK, Lee H, Mallard TT, Bianchi SB, Meredith JJ, Vilar-Ribó L, Xu H, Hatoum AS, Johnson EC, Pazdernik V, Jinwala Z, Pakala SR, Leger BS, Niarchou M, Ehinmowo M; Penn Medicine BioBank, Million Veteran Program, PsycheMERGE Substance Use Disorder Workgroup; Jenkins GD, Batzler A, Pendegraft R, Palmer AA, Zhou H, Biernacka JM, Coombes BJ, Gelernter J, Xu K, Hancock DB, Cox NJ, Smoller JW, Davis LK, Justice AC, Kranzler HR, Kember RL, Sanchez-Roige S. Toikumo S, et al. medRxiv [Preprint]. 2023 Sep 18:2023.03.27.23287713. doi: 10.1101/2023.03.27.23287713. medRxiv. 2023. PMID: 37034728 Free PMC article. Preprint.
Clinical, environmental, and genetic risk factors for substance use disorders: characterizing combined effects across multiple cohorts.
Barr PB, Driver MN, Kuo SI, Stephenson M, Aliev F, Linnér RK, Marks J, Anokhin AP, Bucholz K, Chan G, Edenberg HJ, Edwards AC, Francis MW, Hancock DB, Harden KP, Kamarajan C, Kaprio J, Kinreich S, Kramer JR, Kuperman S, Latvala A, Meyers JL, Palmer AA, Plawecki MH, Porjesz B, Rose RJ, Schuckit MA, Salvatore JE, Dick DM. Barr PB, et al. Mol Psychiatry. 2022 Nov;27(11):4633-4641. doi: 10.1038/s41380-022-01801-6. Mol Psychiatry. 2022. PMID: 36195638 Free PMC article.
Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain.
Tran MN, Maynard KR, Spangler A, Huuki LA, Montgomery KD, Sadashivaiah V, Tippani M, Barry BK, Hancock DB, Hicks SC, Kleinman JE, Hyde TM, Collado-Torres L, Jaffe AE, Martinowich K. Tran MN, et al. Neuron. 2021 Oct 6;109(19):3088-3103.e5. doi: 10.1016/j.neuron.2021.09.001. Epub 2021 Sep 27. Neuron. 2021. PMID: 34582785 Free PMC article.
Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits.
Quach BC, Bray MJ, Gaddis NC, Liu M, Palviainen T, Minica CC, Zellers S, Sherva R, Aliev F, Nothnagel M, Young KA, Marks JA, Young H, Carnes MU, Guo Y, Waldrop A, Sey NYA, Landi MT, McNeil DW, Drichel D, Farrer LA, Markunas CA, Vink JM, Hottenga JJ, Iacono WG, Kranzler HR, Saccone NL, Neale MC, Madden P, Rietschel M, Marazita ML, McGue M, Won H, Winterer G, Grucza R, Dick DM, Gelernter J, Caporaso NE, Baker TB, Boomsma DI, Kaprio J, Hokanson JE, Vrieze S, Bierut LJ, Johnson EO, Hancock DB. Quach BC, et al. Nat Commun. 2020 Nov 3;11(1):5562. doi: 10.1038/s41467-020-19265-z. Nat Commun. 2020. PMID: 33144568 Free PMC article.
Dissecting the genetic overlap of smoking behaviors, lung cancer, and chronic obstructive pulmonary disease: A focus on nicotinic receptors and nicotine metabolizing enzyme.
Bray MJ, Chen LS, Fox L, Hancock DB, Culverhouse RC, Hartz SM, Johnson EO, Liu M, McKay JD, Saccone NL, Hokanson JE, Vrieze SI, Tyndale RF, Baker TB, Bierut LJ. Bray MJ, et al. Genet Epidemiol. 2020 Oct;44(7):748-758. doi: 10.1002/gepi.22331. Epub 2020 Aug 16. Genet Epidemiol. 2020. PMID: 32803792 Free PMC article.
16 results