R01 DK033651/DK/NIDDK NIH HHS/United States[Grants and Funding] - Search Results

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Chronic tissue inflammation and metabolic disease.

Lee YS, Olefsky J. Lee YS, et al. Genes Dev. 2021 Mar 1;35(5-6):307-328. doi: 10.1101/gad.346312.120. Genes Dev. 2021. PMID: 33649162 Free PMC article. Review.

TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance.

El Ouarrat D, Isaac R, Lee YS, Oh DY, Wollam J, Lackey D, Riopel M, Bandyopadhyay G, Seo JB, Sampath-Kumar R, Olefsky JM. El Ouarrat D, et al. Cell Metab. 2020 Jan 7;31(1):162-173.e5. doi: 10.1016/j.cmet.2019.10.003. Epub 2019 Nov 7. Cell Metab. 2020. PMID: 31708444 Free PMC article.

Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance.

Wollam J, Riopel M, Xu YJ, Johnson AMF, Ofrecio JM, Ying W, El Ouarrat D, Chan LS, Han AW, Mahmood NA, Ryan CN, Lee YS, Watrous JD, Chordia MD, Pan D, Jain M, Olefsky JM. Wollam J, et al. Diabetes. 2019 Jul;68(7):1415-1426. doi: 10.2337/db18-1307. Epub 2019 Apr 22. Diabetes. 2019. PMID: 31010956 Free PMC article.

Inflammation and insulin resistance: New targets encourage new thinking: Galectin-3 and LTB₄ are pro-inflammatory molecules that can be targeted to restore insulin sensitivity.

Johnson AMF, Hou S, Li P. Johnson AMF, et al. Bioessays. 2017 Sep;39(9):10.1002/bies.201700036. doi: 10.1002/bies.201700036. Epub 2017 Jul 28. Bioessays. 2017. PMID: 28752547 Free PMC article. Review.

Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling.

Ying W, Wollam J, Ofrecio JM, Bandyopadhyay G, El Ouarrat D, Lee YS, Oh DY, Li P, Osborn O, Olefsky JM. Ying W, et al. J Clin Invest. 2017 Mar 1;127(3):1019-1030. doi: 10.1172/JCI90350. Epub 2017 Feb 13. J Clin Invest. 2017. PMID: 28192375 Free PMC article.

Obese Neuronal PPARγ Knockout Mice Are Leptin Sensitive but Show Impaired Glucose Tolerance and Fertility.

Fernandez MO, Sharma S, Kim S, Rickert E, Hsueh K, Hwang V, Olefsky JM, Webster NJ. Fernandez MO, et al. Endocrinology. 2017 Jan 1;158(1):121-133. doi: 10.1210/en.2016-1818. Endocrinology. 2017. PMID: 27841948 Free PMC article.

Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance.

Li P, Liu S, Lu M, Bandyopadhyay G, Oh D, Imamura T, Johnson AMF, Sears D, Shen Z, Cui B, Kong L, Hou S, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky JM. Li P, et al. Cell. 2016 Nov 3;167(4):973-984.e12. doi: 10.1016/j.cell.2016.10.025. Cell. 2016. PMID: 27814523 Free PMC article.

GPR43 Potentiates β-Cell Function in Obesity.

McNelis JC, Lee YS, Mayoral R, van der Kant R, Johnson AM, Wollam J, Olefsky JM. McNelis JC, et al. Diabetes. 2015 Sep;64(9):3203-17. doi: 10.2337/db14-1938. Epub 2015 May 28. Diabetes. 2015. PMID: 26023106 Free PMC article.

Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity.

Mayoral R, Osborn O, McNelis J, Johnson AM, Oh DY, Izquierdo CL, Chung H, Li P, Traves PG, Bandyopadhyay G, Pessentheiner AR, Ofrecio JM, Cook JR, Qiang L, Accili D, Olefsky JM. Mayoral R, et al. Mol Metab. 2015 Mar 5;4(5):378-91. doi: 10.1016/j.molmet.2015.02.007. eCollection 2015 May. Mol Metab. 2015. PMID: 25973386 Free PMC article.

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes.

Li P, Oh DY, Bandyopadhyay G, Lagakos WS, Talukdar S, Osborn O, Johnson A, Chung H, Maris M, Ofrecio JM, Taguchi S, Lu M, Olefsky JM. Li P, et al. Nat Med. 2015 Mar;21(3):239-247. doi: 10.1038/nm.3800. Epub 2015 Feb 23. Nat Med. 2015. PMID: 25706874 Free PMC article.

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