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Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 3. Role of lysyl and tyrosyl residues of the C-terminal extension.
Biochemistry. 2010 Sep 28;49(38):8434-41. doi: 10.1021/bi1007595.
Biochemistry. 2010.
PMID: 20687591
Free PMC article.
The rationale for targeting the NAD/NADH cofactor binding site of parasitic S-adenosyl-L-homocysteine hydrolase for the design of anti-parasitic drugs.
Cai S, Li QS, Fang J, Borchardt RT, Kuczera K, Middaugh CR, Schowen RL.
Cai S, et al.
Nucleosides Nucleotides Nucleic Acids. 2009 May;28(5):485-503. doi: 10.1080/15257770903051031.
Nucleosides Nucleotides Nucleic Acids. 2009.
PMID: 20183598
Free PMC article.
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Evaluation of NAD(H) analogues as selective inhibitors for Trypanosoma cruzi S-adenosylhomocysteine hydrolase.
Li QS, Cai S, Fang J, Borchardt RT, Kuczera K, Middaugh CR, Schowen RL.
Li QS, et al.
Nucleosides Nucleotides Nucleic Acids. 2009 May;28(5):473-84. doi: 10.1080/15257770903044572.
Nucleosides Nucleotides Nucleic Acids. 2009.
PMID: 20183597
Free PMC article.
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Synthesis of 5'-functionalized nucleosides: S-Adenosylhomocysteine analogues with the carbon-5' and sulfur atoms replaced by a vinyl or halovinyl unit.
Wnuk SF, Sacasa PR, Lewandowska E, Andrei D, Cai S, Borchardt RT.
Wnuk SF, et al.
Bioorg Med Chem. 2008 May 15;16(10):5424-33. doi: 10.1016/j.bmc.2008.04.017. Epub 2008 Apr 12.
Bioorg Med Chem. 2008.
PMID: 18457953
Free PMC article.
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The antiviral drug ribavirin is a selective inhibitor of S-adenosyl-L-homocysteine hydrolase from Trypanosoma cruzi.
Cai S, Li QS, Borchardt RT, Kuczera K, Schowen RL.
Cai S, et al.
Bioorg Med Chem. 2007 Dec 1;15(23):7281-7. doi: 10.1016/j.bmc.2007.08.029. Epub 2007 Aug 24.
Bioorg Med Chem. 2007.
PMID: 17845853
Free PMC article.
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