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Imaging active site chemistry and protonation states: NMR crystallography of the tryptophan synthase α-aminoacrylate intermediate.
Holmes JB, Liu V, Caulkins BG, Hilario E, Ghosh RK, Drago VN, Young RP, Romero JA, Gill AD, Bogie PM, Paulino J, Wang X, Riviere G, Bosken YK, Struppe J, Hassan A, Guidoulianov J, Perrone B, Mentink-Vigier F, Chang CA, Long JR, Hooley RJ, Mueser TC, Dunn MF, Mueller LJ. Holmes JB, et al. Proc Natl Acad Sci U S A. 2022 Jan 11;119(2):e2109235119. doi: 10.1073/pnas.2109235119. Proc Natl Acad Sci U S A. 2022. PMID: 34996869 Free PMC article.
Discovery of antimicrobial agent targeting tryptophan synthase.
Bosken YK, Ai R, Hilario E, Ghosh RK, Dunn MF, Kan SH, Niks D, Zhou H, Ma W, Mueller LJ, Fan L, Chang CA. Bosken YK, et al. Protein Sci. 2022 Feb;31(2):432-442. doi: 10.1002/pro.4236. Epub 2021 Nov 26. Protein Sci. 2022. PMID: 34767267 Free PMC article.
34 results