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Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities.
Mallard TT, Linnér RK, Grotzinger AD, Sanchez-Roige S, Seidlitz J, Okbay A, de Vlaming R, Meddens SFW; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium; Palmer AA, Davis LK, Tucker-Drob EM, Kendler KS, Keller MC, Koellinger PD, Harden KP. Mallard TT, et al. Cell Genom. 2022 Jun 8;2(6):100140. doi: 10.1016/j.xgen.2022.100140. Epub 2022 Jun 8. Cell Genom. 2022. PMID: 35812988 Free PMC article.
Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis.
Grotzinger AD, Mallard TT, Akingbuwa WA, Ip HF, Adams MJ, Lewis CM, McIntosh AM, Grove J, Dalsgaard S, Lesch KP, Strom N, Meier SM, Mattheisen M, Børglum AD, Mors O, Breen G; iPSYCH; Tourette Syndrome and Obsessive Compulsive Disorder Working Group of the Psychiatric Genetics Consortium; Bipolar Disorder Working Group of the Psychiatric Genetics Consortium; Major Depressive Disorder Working Group of the Psychiatric Genetics Consortium; Schizophrenia Working Group of the Psychiatric Genetics Consortium; Lee PH, Kendler KS, Smoller JW, Tucker-Drob EM, Nivard MG. Grotzinger AD, et al. Nat Genet. 2022 May;54(5):548-559. doi: 10.1038/s41588-022-01057-4. Epub 2022 May 5. Nat Genet. 2022. PMID: 35513722 Free PMC article.
57 results