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2014 2
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Page 1
Functional insights from biophysical study of TREM2 interactions with apoE and Aβ1-42.
Kober DL, Stuchell-Brereton MD, Kluender CE, Dean HB, Strickland MR, Steinberg DF, Nelson SS, Baban B, Holtzman DM, Frieden C, Alexander-Brett J, Roberson ED, Song Y, Brett TJ. Kober DL, et al. Alzheimers Dement. 2020 Oct 8:10.1002/alz.12194. doi: 10.1002/alz.12194. Online ahead of print. Alzheimers Dement. 2020. PMID: 33090700 Free PMC article.
Overlapping genetic architecture between Parkinson disease and melanoma.
Dube U, Ibanez L, Budde JP, Benitez BA, Davis AA, Harari O, Iles MM, Law MH, Brown KM; 23andMe Research Team; Melanoma-Meta-analysis Consortium; Cruchaga C. Dube U, et al. Acta Neuropathol. 2020 Feb;139(2):347-364. doi: 10.1007/s00401-019-02110-z. Epub 2019 Dec 16. Acta Neuropathol. 2020. PMID: 31845298 Free PMC article.
The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion.
Li Z, Farias FHG, Dube U, Del-Aguila JL, Mihindukulasuriya KA, Fernandez MV, Ibanez L, Budde JP, Wang F, Lake AM, Deming Y, Perez J, Yang C, Bahena JA, Qin W, Bradley JL, Davenport R, Bergmann K, Morris JC, Perrin RJ, Benitez BA, Dougherty JD, Harari O, Cruchaga C. Li Z, et al. Acta Neuropathol. 2020 Jan;139(1):45-61. doi: 10.1007/s00401-019-02066-0. Epub 2019 Aug 27. Acta Neuropathol. 2020. PMID: 31456032 Free PMC article.
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk.
Deming Y, Filipello F, Cignarella F, Cantoni C, Hsu S, Mikesell R, Li Z, Del-Aguila JL, Dube U, Farias FG, Bradley J, Budde J, Ibanez L, Fernandez MV, Blennow K, Zetterberg H, Heslegrave A, Johansson PM, Svensson J, Nellgård B, Lleo A, Alcolea D, Clarimon J, Rami L, Molinuevo JL, Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Ewers M, Harari O, Haass C, Brett TJ, Benitez BA, Karch CM, Piccio L, Cruchaga C. Deming Y, et al. Sci Transl Med. 2019 Aug 14;11(505):eaau2291. doi: 10.1126/scitranslmed.aau2291. Sci Transl Med. 2019. PMID: 31413141 Free PMC article.
The Ebola Viral Protein 35 N-Terminus Is a Parallel Tetramer.
Chanthamontri CK, Jordan DS, Wang W, Wu C, Lin Y, Brett TJ, Gross ML, Leung DW. Chanthamontri CK, et al. Biochemistry. 2019 Feb 12;58(6):657-664. doi: 10.1021/acs.biochem.8b01154. Epub 2019 Jan 10. Biochemistry. 2019. PMID: 30592210 Free PMC article.
TREM2-Ligand Interactions in Health and Disease.
Kober DL, Brett TJ. Kober DL, et al. J Mol Biol. 2017 Jun 2;429(11):1607-1629. doi: 10.1016/j.jmb.2017.04.004. Epub 2017 Apr 19. J Mol Biol. 2017. PMID: 28432014 Free PMC article. Review.
24 results