R21 AI125973/AI/NIAID NIH HHS/United States[Grants and Funding] - Search Results

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Subject: R21 AI125973/AI/NIAID NIH HHS/United States[Grant - PubMed

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Year	Number of Results
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2021	3
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Nanoconfinement and Crowding Enhanced Single-Molecule Detection of Small Molecules with Nanopipettes.

Khatri S, Pandey P, Mejia G, Ghimire G, Leng F, He J. Khatri S, et al. J Am Chem Soc. 2023 Dec 27;145(51):28075-28084. doi: 10.1021/jacs.3c09311. Epub 2023 Nov 23. J Am Chem Soc. 2023. PMID: 37996390

Macromolecular crowding potently stimulates DNA supercoiling activity of Mycobacterium tuberculosis DNA gyrase.

Deng Z, Chapagain P, Leng F. Deng Z, et al. J Biol Chem. 2023 Dec;299(12):105439. doi: 10.1016/j.jbc.2023.105439. Epub 2023 Nov 7. J Biol Chem. 2023. PMID: 37944619 Free PMC article.

Polyheterocyclic peptidomimetics: Parallel solid phase synthesis of oligo cyclic guanidines and their inhibition activity against Mycobacterium tuberculosis DNA gyrase.

Tantak M, Rayala R, Deng Z, Bunnell A, Wang T, Chaudhari P, Leng F, Nefzi A. Tantak M, et al. Bioorg Med Chem Lett. 2023 Sep 1;93:129439. doi: 10.1016/j.bmcl.2023.129439. Epub 2023 Aug 8. Bioorg Med Chem Lett. 2023. PMID: 37557925

Anticancer Drug Doxorubicin Spontaneously Reacts with GTP and dGTP.

Mejia G, Su L, Pandey P, Jeanne Dit Fouque K, McGoron AJ, Fernandez-Lima F, He J, Mebel AM, Leng F. Mejia G, et al. Chem Res Toxicol. 2023 Apr 17;36(4):660-668. doi: 10.1021/acs.chemrestox.2c00367. Epub 2023 Mar 31. Chem Res Toxicol. 2023. PMID: 37000908

Novel and Structurally Diversified Bacterial DNA Gyrase Inhibitors Discovered through a Fluorescence-Based High-Throughput Screening Assay.

Alfonso EE, Deng Z, Boaretto D, Hood BL, Vasile S, Smith LH, Chambers JW, Chapagain P, Leng F. Alfonso EE, et al. ACS Pharmacol Transl Sci. 2022 Sep 2;5(10):932-944. doi: 10.1021/acsptsci.2c00113. eCollection 2022 Oct 14. ACS Pharmacol Transl Sci. 2022. PMID: 36268121 Free PMC article.

Potent Inhibition of Bacterial DNA Gyrase by Digallic Acid and Other Gallate Derivatives.

Alfonso EE, Troche R, Deng Z, Annamalai T, Chapagain P, Tse-Dinh YC, Leng F. Alfonso EE, et al. ChemMedChem. 2022 Dec 5;17(23):e202200301. doi: 10.1002/cmdc.202200301. Epub 2022 Oct 19. ChemMedChem. 2022. PMID: 36161274 Free PMC article.

Exploring the Conformational and Binding Dynamics of HMGA2·DNA Complexes Using Trapped Ion Mobility Spectrometry-Mass Spectrometry.

Jeanne Dit Fouque K, Sipe SN, Garabedian A, Mejia G, Su L, Hossen ML, Chapagain PP, Leng F, Brodbelt JS, Fernandez-Lima F. Jeanne Dit Fouque K, et al. J Am Soc Mass Spectrom. 2022 Jul 6;33(7):1103-1112. doi: 10.1021/jasms.2c00101. Epub 2022 Jun 10. J Am Soc Mass Spectrom. 2022. PMID: 35687119 Free PMC article.

AT-hook peptides bind the major and minor groove of AT-rich DNA duplexes.

Garabedian A, Jeanne Dit Fouque K, Chapagain PP, Leng F, Fernandez-Lima F. Garabedian A, et al. Nucleic Acids Res. 2022 Mar 21;50(5):2431-2439. doi: 10.1093/nar/gkac115. Nucleic Acids Res. 2022. PMID: 35212375 Free PMC article.

Detecting Individual Proteins and Their Surface Charge Variations in Solution by the Potentiometric Nanoimpact Method.

Pandey P, Bhattarai N, Su L, Wang X, Leng F, Gerstman B, Chapagain PP, He J. Pandey P, et al. ACS Sens. 2022 Feb 25;7(2):555-563. doi: 10.1021/acssensors.1c02385. Epub 2022 Jan 21. ACS Sens. 2022. PMID: 35060380 Free PMC article.

Negative DNA supercoiling makes protein-mediated looping deterministic and ergodic within the bacterial doubling time.

Yan Y, Xu W, Kumar S, Zhang A, Leng F, Dunlap D, Finzi L. Yan Y, et al. Nucleic Acids Res. 2021 Nov 18;49(20):11550-11559. doi: 10.1093/nar/gkab946. Nucleic Acids Res. 2021. PMID: 34723343 Free PMC article.

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