R21 NS067354/NS/NINDS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2010	3
2011	3
2012	3
2013	3
2014	4
2015	1
2017	2
2024	0

1

Designer protein disaggregases to counter neurodegenerative disease.

Shorter J. Shorter J. Curr Opin Genet Dev. 2017 Jun;44:1-8. doi: 10.1016/j.gde.2017.01.008. Epub 2017 Feb 14. Curr Opin Genet Dev. 2017. PMID: 28208059 Free PMC article. Review.

2

Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies.

Guo L, Shorter J. Guo L, et al. Cold Spring Harb Perspect Med. 2017 Sep 1;7(9):a024554. doi: 10.1101/cshperspect.a024554. Cold Spring Harb Perspect Med. 2017. PMID: 27920024 Free PMC article. Review.

3

Chaperones in Neurodegeneration.

Lindberg I, Shorter J, Wiseman RL, Chiti F, Dickey CA, McLean PJ. Lindberg I, et al. J Neurosci. 2015 Oct 14;35(41):13853-9. doi: 10.1523/JNEUROSCI.2600-15.2015. J Neurosci. 2015. PMID: 26468185 Free PMC article. Review.

4

Isolating potentiated Hsp104 variants using yeast proteinopathy models.

Jackrel ME, Tariq A, Yee K, Weitzman R, Shorter J. Jackrel ME, et al. J Vis Exp. 2014 Nov 11;(93):e52089. doi: 10.3791/52089. J Vis Exp. 2014. PMID: 25407485 Free PMC article.

5

Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins.

Jackrel ME, Shorter J. Jackrel ME, et al. Dis Model Mech. 2014 Oct;7(10):1175-84. doi: 10.1242/dmm.016113. Epub 2014 Jul 25. Dis Model Mech. 2014. PMID: 25062688 Free PMC article.

6

Reversing deleterious protein aggregation with re-engineered protein disaggregases.

Jackrel ME, Shorter J. Jackrel ME, et al. Cell Cycle. 2014;13(9):1379-83. doi: 10.4161/cc.28709. Epub 2014 Apr 2. Cell Cycle. 2014. PMID: 24694655 Free PMC article.

7

Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events.

Jackrel ME, DeSantis ME, Martinez BA, Castellano LM, Stewart RM, Caldwell KA, Caldwell GA, Shorter J. Jackrel ME, et al. Cell. 2014 Jan 16;156(1-2):170-82. doi: 10.1016/j.cell.2013.11.047. Cell. 2014. PMID: 24439375 Free PMC article.

8

Stress granules as crucibles of ALS pathogenesis.

Li YR, King OD, Shorter J, Gitler AD. Li YR, et al. J Cell Biol. 2013 Apr 29;201(3):361-72. doi: 10.1083/jcb.201302044. J Cell Biol. 2013. PMID: 23629963 Free PMC article. Review.

9

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.

Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, MacLea KS, Freibaum B, Li S, Molliex A, Kanagaraj AP, Carter R, Boylan KB, Wojtas AM, Rademakers R, Pinkus JL, Greenberg SA, Trojanowski JQ, Traynor BJ, Smith BN, Topp S, Gkazi AS, Miller J, Shaw CE, Kottlors M, Kirschner J, Pestronk A, Li YR, Ford AF, Gitler AD, Benatar M, King OD, Kimonis VE, Ross ED, Weihl CC, Shorter J, Taylor JP. Kim HJ, et al. Nature. 2013 Mar 28;495(7442):467-73. doi: 10.1038/nature11922. Epub 2013 Mar 3. Nature. 2013. PMID: 23455423 Free PMC article.

10

Disease mutations in the prion-like domains of hnRNPA1 and hnRNPA2/B1 introduce potent steric zippers that drive excess RNP granule assembly.

Shorter J, Taylor JP. Shorter J, et al. Rare Dis. 2013 May 29;1:e25200. doi: 10.4161/rdis.25200. eCollection 2013. Rare Dis. 2013. PMID: 25002999 Free PMC article.

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