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Year Number of Results
1997 1
2000 4
2001 3
2003 1
2004 1
2006 1
2007 2
2008 2
2009 6
2010 2
2011 4
2012 7
2013 4
2014 2
2018 1
2024 0

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Page 1
A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties.
Tamir S, Eisenberg-Domovich Y, Conlan AR, Stofleth JT, Lipper CH, Paddock ML, Mittler R, Jennings PA, Livnah O, Nechushtai R. Tamir S, et al. Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1572-8. doi: 10.1107/S1399004714005458. Epub 2014 May 23. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 24914968 Free PMC article.
Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.
Tamir S, Rotem-Bamberger S, Katz C, Morcos F, Hailey KL, Zuris JA, Wang C, Conlan AR, Lipper CH, Paddock ML, Mittler R, Onuchic JN, Jennings PA, Friedler A, Nechushtai R. Tamir S, et al. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5177-82. doi: 10.1073/pnas.1403770111. Epub 2014 Mar 25. Proc Natl Acad Sci U S A. 2014. PMID: 24706857 Free PMC article.
NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth.
Sohn YS, Tamir S, Song L, Michaeli D, Matouk I, Conlan AR, Harir Y, Holt SH, Shulaev V, Paddock ML, Hochberg A, Cabanchick IZ, Onuchic JN, Jennings PA, Nechushtai R, Mittler R. Sohn YS, et al. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14676-81. doi: 10.1073/pnas.1313198110. Epub 2013 Aug 19. Proc Natl Acad Sci U S A. 2013. PMID: 23959881 Free PMC article.
Allosteric control in a metalloprotein dramatically alters function.
Baxter EL, Zuris JA, Wang C, Vo PL, Axelrod HL, Cohen AE, Paddock ML, Nechushtai R, Onuchic JN, Jennings PA. Baxter EL, et al. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):948-53. doi: 10.1073/pnas.1208286110. Epub 2012 Dec 27. Proc Natl Acad Sci U S A. 2013. PMID: 23271805 Free PMC article.
40 results