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Genome-wide association study identifies the common variants in CYP3A4 and CYP3A5 responsible for variation in tacrolimus trough concentration in Caucasian kidney transplant recipients.
Oetting WS, Wu B, Schladt DP, Guan W, Remmel RP, Mannon RB, Matas AJ, Israni AK, Jacobson PA. Oetting WS, et al. Among authors: remmel rp. Pharmacogenomics J. 2018 May 22;18(3):501-505. doi: 10.1038/tpj.2017.49. Epub 2017 Nov 21. Pharmacogenomics J. 2018. PMID: 29160300 Free PMC article.
Multigene predictors of tacrolimus exposure in kidney transplant recipients.
Pulk RA, Schladt DS, Oetting WS, Guan W, Israni AK, Matas AJ, Remmel RP, Jacobson PA; DeKAF Investigators. Pulk RA, et al. Among authors: remmel rp. Pharmacogenomics. 2015 Jul;16(8):841-54. doi: 10.2217/pgs.15.42. Epub 2015 Jun 12. Pharmacogenomics. 2015. PMID: 26067485 Free PMC article.
Tacrolimus trough and dose intra-patient variability and CYP3A5 genotype: Effects on acute rejection and graft failure in European American and African American kidney transplant recipients.
Seibert SR, Schladt DP, Wu B, Guan W, Dorr C, Remmel RP, Matas AJ, Mannon RB, Israni AK, Oetting WS, Jacobson PA. Seibert SR, et al. Among authors: remmel rp. Clin Transplant. 2018 Dec;32(12):e13424. doi: 10.1111/ctr.13424. Epub 2018 Oct 31. Clin Transplant. 2018. PMID: 30318646 Free PMC article.
Identification of genetic variants associated with tacrolimus metabolism in kidney transplant recipients by extreme phenotype sampling and next generation sequencing.
Dorr CR, Wu B, Remmel RP, Muthusamy A, Schladt DP, Abrahante JE, Guan W, Mannon RB, Matas AJ, Oetting WS, Jacobson PA, Israni AK; for DeKAF Genomics. Dorr CR, et al. Among authors: remmel rp. Pharmacogenomics J. 2019 Aug;19(4):375-389. doi: 10.1038/s41397-018-0063-z. Epub 2018 Nov 16. Pharmacogenomics J. 2019. PMID: 30442921 Free PMC article.
Analysis of 75 Candidate SNPs Associated With Acute Rejection in Kidney Transplant Recipients: Validation of rs2910164 in MicroRNA MIR146A.
Oetting WS, Schladt DP, Dorr CR, Wu B, Guan W, Remmel RP, Iklé D, Mannon RB, Matas AJ, Israni AK, Jacobson PA; DeKAF Genomics and GEN03 Investigators. Oetting WS, et al. Among authors: remmel rp. Transplantation. 2019 Aug;103(8):1591-1602. doi: 10.1097/TP.0000000000002659. Transplantation. 2019. PMID: 30801535 Free PMC article.
Genetic Variants Associated With Immunosuppressant Pharmacokinetics and Adverse Effects in the DeKAF Genomics Genome-wide Association Studies.
Oetting WS, Wu B, Schladt DP, Guan W, van Setten J, Keating BJ, Iklé D, Remmel RP, Dorr CR, Mannon RB, Matas AJ, Israni AK, Jacobson PA; DeKAF Genomics and GEN-03 Investigators. Oetting WS, et al. Among authors: remmel rp. Transplantation. 2019 Jun;103(6):1131-1139. doi: 10.1097/TP.0000000000002625. Transplantation. 2019. PMID: 30801552 Free PMC article.
Tacrolimus troughs and genetic determinants of metabolism in kidney transplant recipients: A comparison of four ancestry groups.
Mohamed ME, Schladt DP, Guan W, Wu B, van Setten J, Keating BJ, Iklé D, Remmel RP, Dorr CR, Mannon RB, Matas AJ, Israni AK, Oetting WS, Jacobson PA; DeKAF Genomics and GEN03 Investigators. Mohamed ME, et al. Among authors: remmel rp. Am J Transplant. 2019 Oct;19(10):2795-2804. doi: 10.1111/ajt.15385. Epub 2019 May 13. Am J Transplant. 2019. PMID: 30953600 Free PMC article.
141 results