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Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in rats and inhibits Na+ uptake in humans.
Spencer AG, Labonte ED, Rosenbaum DP, Plato CF, Carreras CW, Leadbetter MR, Kozuka K, Kohler J, Koo-McCoy S, He L, Bell N, Tabora J, Joly KM, Navre M, Jacobs JW, Charmot D. Spencer AG, et al. Among authors: rosenbaum dp. Sci Transl Med. 2014 Mar 12;6(227):227ra36. doi: 10.1126/scitranslmed.3007790. Sci Transl Med. 2014. PMID: 24622516 Clinical Trial.
Effect of Tenapanor on Interdialytic Weight Gain in Patients on Hemodialysis.
Block GA, Rosenbaum DP, Leonsson-Zachrisson M, Stefansson BV, Rydén-Bergsten T, Greasley PJ, Johansson SA, Knutsson M, Carlsson BC. Block GA, et al. Among authors: rosenbaum dp. Clin J Am Soc Nephrol. 2016 Sep 7;11(9):1597-1605. doi: 10.2215/CJN.09050815. Epub 2016 Jun 23. Clin J Am Soc Nephrol. 2016. PMID: 27340281 Free PMC article. Clinical Trial.
Preclinical and Healthy Volunteer Studies of Potential Drug-Drug Interactions Between Tenapanor and Phosphate Binders.
Johansson S, Leonsson-Zachrisson M, Knutsson M, Spencer AG, Labonté ED, Deshpande D, Kohler J, Kozuka K, Charmot D, Rosenbaum DP. Johansson S, et al. Among authors: rosenbaum dp. Clin Pharmacol Drug Dev. 2017 Sep;6(5):448-456. doi: 10.1002/cpdd.307. Epub 2016 Oct 26. Clin Pharmacol Drug Dev. 2017. PMID: 27654985 Free PMC article. Clinical Trial.
Effect of Food Intake on the Pharmacodynamics of Tenapanor: A Phase 1 Study.
Johansson SA, Knutsson M, Leonsson-Zachrisson M, Rosenbaum DP. Johansson SA, et al. Among authors: rosenbaum dp. Clin Pharmacol Drug Dev. 2017 Sep;6(5):457-465. doi: 10.1002/cpdd.341. Epub 2017 Mar 24. Clin Pharmacol Drug Dev. 2017. PMID: 28339149 Free PMC article. Clinical Trial.
51 results