Rotonda J - Search Results

1

Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.

Becker JW, Rotonda J, Soisson SM, Aspiotis R, Bayly C, Francoeur S, Gallant M, Garcia-Calvo M, Giroux A, Grimm E, Han Y, McKay D, Nicholson DW, Peterson E, Renaud J, Roy S, Thornberry N, Zamboni R. Becker JW, et al. Among authors: rotonda j. J Med Chem. 2004 May 6;47(10):2466-74. doi: 10.1021/jm0305523. J Med Chem. 2004. PMID: 15115390

2

Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.

Han Y, Giroux A, Grimm EL, Aspiotis R, Francoeur S, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt JP, Rasper DM, Tam J, Tawa P, Thornberry NA, Paterson EP, Garcia-Calvo M, Becker JW, Rotonda J, Nicholson DW, Zamboni RJ. Han Y, et al. Among authors: rotonda j. Bioorg Med Chem Lett. 2004 Feb 9;14(3):805-8. doi: 10.1016/j.bmcl.2003.10.064. Bioorg Med Chem Lett. 2004. PMID: 14741294

3

The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1.

Rotonda J, Garcia-Calvo M, Bull HG, Geissler WM, McKeever BM, Willoughby CA, Thornberry NA, Becker JW. Rotonda J, et al. Chem Biol. 2001 Apr;8(4):357-68. doi: 10.1016/s1074-5521(01)00018-7. Chem Biol. 2001. PMID: 11325591

4

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis.

Rotonda J, Nicholson DW, Fazil KM, Gallant M, Gareau Y, Labelle M, Peterson EP, Rasper DM, Ruel R, Vaillancourt JP, Thornberry NA, Becker JW. Rotonda J, et al. Nat Struct Biol. 1996 Jul;3(7):619-25. doi: 10.1038/nsb0796-619. Nat Struct Biol. 1996. PMID: 8673606

5

A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE).

Rano TA, Timkey T, Peterson EP, Rotonda J, Nicholson DW, Becker JW, Chapman KT, Thornberry NA. Rano TA, et al. Among authors: rotonda j. Chem Biol. 1997 Feb;4(2):149-55. doi: 10.1016/s1074-5521(97)90258-1. Chem Biol. 1997. PMID: 9190289

6

32-Indolyl ether derivatives of ascomycin: three-dimensional structures of complexes with FK506-binding protein.

Becker JW, Rotonda J, Cryan JG, Martin M, Parsons WH, Sinclair PJ, Wiederrecht G, Wong F. Becker JW, et al. Among authors: rotonda j. J Med Chem. 1999 Jul 29;42(15):2798-804. doi: 10.1021/jm9806042. J Med Chem. 1999. PMID: 10425089

7

Improved calcineurin inhibition by yeast FKBP12-drug complexes. Crystallographic and functional analysis.

Rotonda J, Burbaum JJ, Chan HK, Marcy AI, Becker JW. Rotonda J, et al. J Biol Chem. 1993 Apr 15;268(11):7607-9. doi: 10.2210/pdb1yat/pdb. J Biol Chem. 1993. PMID: 7681823 Free article.

8

FK-506-binding protein: three-dimensional structure of the complex with the antagonist L-685,818.

Becker JW, Rotonda J, McKeever BM, Chan HK, Marcy AI, Wiederrecht G, Hermes JD, Springer JP. Becker JW, et al. Among authors: rotonda j. J Biol Chem. 1993 May 25;268(15):11335-9. J Biol Chem. 1993. PMID: 7684380 Free article.

9

Long-term treatment with finasteride 1 mg decreases the likelihood of developing further visible hair loss in men with androgenetic alopecia (male pattern hair loss).

Kaufman KD, Rotonda J, Shah AK, Meehan AG. Kaufman KD, et al. Among authors: rotonda j. Eur J Dermatol. 2008 Jul-Aug;18(4):400-6. doi: 10.1684/ejd.2008.0436. Epub 2008 Jun 23. Eur J Dermatol. 2008. PMID: 18573712 Clinical Trial.

10

Progression of hair loss in men with androgenetic alopecia (male pattern hair loss): long-term (5-year) controlled observational data in placebo-treated patients.

Kaufman KD, Girman CJ, Round EM, Johnson-Levonas AO, Shah AK, Rotonda J. Kaufman KD, et al. Among authors: rotonda j. Eur J Dermatol. 2008 Jul-Aug;18(4):407-11. doi: 10.1684/ejd.2008.0435. Epub 2008 Jun 23. Eur J Dermatol. 2008. PMID: 18573713 Clinical Trial.

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