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Prolonged Correction of Serum Phosphorus in Adults With X-Linked Hypophosphatemia Using Monthly Doses of KRN23.
Imel EA, Zhang X, Ruppe MD, Weber TJ, Klausner MA, Ito T, Vergeire M, Humphrey JS, Glorieux FH, Portale AA, Insogna K, Peacock M, Carpenter TO. Imel EA, et al. Among authors: ruppe md. J Clin Endocrinol Metab. 2015 Jul;100(7):2565-73. doi: 10.1210/jc.2015-1551. Epub 2015 Apr 28. J Clin Endocrinol Metab. 2015. PMID: 25919461 Free PMC article. Clinical Trial.
A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial Evaluating the Efficacy of Burosumab, an Anti-FGF23 Antibody, in Adults With X-Linked Hypophosphatemia: Week 24 Primary Analysis.
Insogna KL, Briot K, Imel EA, Kamenický P, Ruppe MD, Portale AA, Weber T, Pitukcheewanont P, Cheong HI, Jan de Beur S, Imanishi Y, Ito N, Lachmann RH, Tanaka H, Perwad F, Zhang L, Chen CY, Theodore-Oklota C, Mealiffe M, San Martin J, Carpenter TO; AXLES 1 Investigators. Insogna KL, et al. Among authors: ruppe md. J Bone Miner Res. 2018 Aug;33(8):1383-1393. doi: 10.1002/jbmr.3475. Epub 2018 Jun 26. J Bone Miner Res. 2018. PMID: 29947083 Free article. Clinical Trial.
Randomized trial of the anti-FGF23 antibody KRN23 in X-linked hypophosphatemia.
Carpenter TO, Imel EA, Ruppe MD, Weber TJ, Klausner MA, Wooddell MM, Kawakami T, Ito T, Zhang X, Humphrey J, Insogna KL, Peacock M. Carpenter TO, et al. Among authors: ruppe md. J Clin Invest. 2014 Apr;124(4):1587-97. doi: 10.1172/JCI72829. Epub 2014 Feb 24. J Clin Invest. 2014. PMID: 24569459 Free PMC article. Clinical Trial.
Pharmacokinetics and pharmacodynamics of a human monoclonal anti-FGF23 antibody (KRN23) in the first multiple ascending-dose trial treating adults with X-linked hypophosphatemia.
Zhang X, Imel EA, Ruppe MD, Weber TJ, Klausner MA, Ito T, Vergeire M, Humphrey J, Glorieux FH, Portale AA, Insogna K, Carpenter TO, Peacock M. Zhang X, et al. Among authors: ruppe md. J Clin Pharmacol. 2016 Feb;56(2):176-85. doi: 10.1002/jcph.570. Epub 2015 Aug 11. J Clin Pharmacol. 2016. PMID: 26073451 Free PMC article. Clinical Trial.
Medications that affect calcium.
Ruppe MD. Ruppe MD. Endocr Pract. 2011 Mar-Apr;17 Suppl 1:26-30. doi: 10.4158/EP10281.RA. Endocr Pract. 2011. PMID: 21134875 Review.
Kaposi sarcoma in the setting of cushing disease.
Jeng L, Rios A, Ruppe MD. Jeng L, et al. Among authors: ruppe md. Endocr Pract. 2011 Jul-Aug;17(4):e87-91. doi: 10.4158/EP10355.CR. Endocr Pract. 2011. PMID: 21550958
Vitamin D receptors and parathyroid glands.
Landry CS, Ruppe MD, Grubbs EG. Landry CS, et al. Among authors: ruppe md. Endocr Pract. 2011 Mar-Apr;17 Suppl 1:63-8. doi: 10.4158/EP10325.RA. Endocr Pract. 2011. PMID: 21454240 Review.
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