Rushmore TH - Search Results

1

Effect of quinidine on the 10-hydroxylation of R-warfarin: species differences and clearance projection.

Chen Q, Tan E, Strauss JR, Zhang Z, Fenyk-Melody JE, Booth-Genthe C, Rushmore TH, Stearns RA, Evans DC, Baillie TA, Tang W. Chen Q, et al. Among authors: rushmore th. J Pharmacol Exp Ther. 2004 Oct;311(1):307-14. doi: 10.1124/jpet.104.069955. Epub 2004 May 26. J Pharmacol Exp Ther. 2004. PMID: 15163679

2

Diclofenac hydroxylation in monkeys: efficiency, regioselectivity, and response to inhibitors.

Tang C, Fang Y, Booth-Genthe C, Kuo Y, Kuduk SD, Rushmore TH, Carr BA. Tang C, et al. Among authors: rushmore th. Biochem Pharmacol. 2007 Mar 15;73(6):880-90. doi: 10.1016/j.bcp.2006.11.016. Epub 2006 Nov 25. Biochem Pharmacol. 2007. PMID: 17223083

3

Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.

Tang W, Stearns RA, Bandiera SM, Zhang Y, Raab C, Braun MP, Dean DC, Pang J, Leung KH, Doss GA, Strauss JR, Kwei GY, Rushmore TH, Chiu SH, Baillie TA. Tang W, et al. Among authors: rushmore th. Drug Metab Dispos. 1999 Mar;27(3):365-72. Drug Metab Dispos. 1999. PMID: 10064567

4

Role of a potent inhibitory monoclonal antibody to cytochrome P-450 3A4 in assessment of human drug metabolism.

Mei Q, Tang C, Assang C, Lin Y, Slaughter D, Rodrigues AD, Baillie TA, Rushmore TH, Shou M. Mei Q, et al. Among authors: rushmore th. J Pharmacol Exp Ther. 1999 Nov;291(2):749-59. J Pharmacol Exp Ther. 1999. PMID: 10525096

5

Characterization of the rhesus monkey CYP3A64 enzyme: species comparisons of CYP3A substrate specificity and kinetics using baculovirus-expressed recombinant enzymes.

Carr B, Norcross R, Fang Y, Lu P, Rodrigues AD, Shou M, Rushmore T, Booth-Genthe C. Carr B, et al. Drug Metab Dispos. 2006 Oct;34(10):1703-12. doi: 10.1124/dmd.106.009977. Epub 2006 Jun 30. Drug Metab Dispos. 2006. PMID: 16815964

6

Activators of the rat pregnane X receptor differentially modulate hepatic and intestinal gene expression.

Hartley DP, Dai X, He YD, Carlini EJ, Wang B, Huskey SE, Ulrich RG, Rushmore TH, Evers R, Evans DC. Hartley DP, et al. Among authors: rushmore th. Mol Pharmacol. 2004 May;65(5):1159-71. doi: 10.1124/mol.65.5.1159. Mol Pharmacol. 2004. PMID: 15102944

7

Testosterone, 7-benzyloxyquinoline, and 7-benzyloxy-4-trifluoromethyl-coumarin bind to different domains within the active site of cytochrome P450 3A4.

Lu P, Lin Y, Rodrigues AD, Rushmore TH, Baillie TA, Shou M. Lu P, et al. Among authors: rushmore th. Drug Metab Dispos. 2001 Nov;29(11):1473-9. Drug Metab Dispos. 2001. PMID: 11602524

8

Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives.

Shou M, Mei Q, Ettore MW Jr, Dai R, Baillie TA, Rushmore TH. Shou M, et al. Among authors: rushmore th. Biochem J. 1999 Jun 15;340 ( Pt 3)(Pt 3):845-53. Biochem J. 1999. PMID: 10359672 Free PMC article.

9

Induction of CYP1A in the beagle dog by an inhibitor of kinase insert domain-containing receptor: differential effects in vitro and in vivo on mRNA and functional activity.

Gibson CR, Lin C, Singh R, Brown CM, Richards K, Brunner J, Michel K, Adelsberger J, Carlini E, Boothe-Genthe C, Raab C, Luu M, Michael A, Parikh M, Ciecko P, Subramanian R, Krolikowski P, Rodrigues AD, Baillie TA, Rushmore TH. Gibson CR, et al. Among authors: rushmore th. Drug Metab Dispos. 2005 Jul;33(7):1044-51. doi: 10.1124/dmd.105.003913. Epub 2005 Apr 15. Drug Metab Dispos. 2005. PMID: 15833927

10

Development and characterization of LLC-PK1 cells containing Sprague-Dawley rat Abcb1a (Mdr1a): comparison of rat P-glycoprotein transport to human and mouse.

Booth-Genthe CL, Louie SW, Carlini EJ, Li B, Leake BF, Eisenhandler R, Hochman JH, Mei Q, Kim RB, Rushmore TH, Yamazaki M. Booth-Genthe CL, et al. Among authors: rushmore th. J Pharmacol Toxicol Methods. 2006 Jul-Aug;54(1):78-89. doi: 10.1016/j.vascn.2005.12.004. Epub 2006 Mar 20. J Pharmacol Toxicol Methods. 2006. PMID: 16545584

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