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Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose-associated 90-Day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE III).
Am J Respir Crit Care Med. 2023 Apr 1;207(7):876-886. doi: 10.1164/rccm.202206-1208OC.
Am J Respir Crit Care Med. 2023.
PMID: 36215171
Clinical Trial.
Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial.
Shehabi Y, Serpa Neto A, Howe BD, Bellomo R, Arabi YM, Bailey M, Bass FE, Kadiman SB, McArthur CJ, Reade MC, Seppelt IM, Takala J, Wise MP, Webb SA; SPICE III Study Investigators.
Shehabi Y, et al.
Intensive Care Med. 2021 Apr;47(4):455-466. doi: 10.1007/s00134-021-06356-8. Epub 2021 Mar 8.
Intensive Care Med. 2021.
PMID: 33686482
Free PMC article.
Clinical Trial.
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The SPICE III study protocol and analysis plan: a randomised trial of early goaldirected sedation compared with standard care in mechanically ventilated patients.
Shehabi Y, Forbes AB, Arabi Y, Bass F, Bellomo R, Kadiman S, Howe BD, McArthur C, Reade MC, Seppelt I, Takala J, Webb S, Wise MP; The SPICE III study investigators; The Australian and New Zealand Intensive Care Society Clinical Trials Group; The Australian and New Zealand Intensive Care Research Centre.
Shehabi Y, et al.
Crit Care Resusc. 2017 Dec;19(4):318-326.
Crit Care Resusc. 2017.
PMID: 29202258
Clinical Trial.
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