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Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium.
Polimanti R, Walters RK, Johnson EC, McClintick JN, Adkins AE, Adkins DE, Bacanu SA, Bierut LJ, Bigdeli TB, Brown S, Bucholz KK, Copeland WE, Costello EJ, Degenhardt L, Farrer LA, Foroud TM, Fox L, Goate AM, Grucza R, Hack LM, Hancock DB, Hartz SM, Heath AC, Hewitt JK, Hopfer CJ, Johnson EO, Kendler KS, Kranzler HR, Krauter K, Lai D, Madden PAF, Martin NG, Maes HH, Nelson EC, Peterson RE, Porjesz B, Riley BP, Saccone N, Stallings M, Wall TL, Webb BT, Wetherill L; Psychiatric Genomics Consortium Substance Use Disorders Workgroup; Edenberg HJ, Agrawal A, Gelernter J. Polimanti R, et al. Among authors: saccone n. Mol Psychiatry. 2020 Aug;25(8):1673-1687. doi: 10.1038/s41380-020-0677-9. Epub 2020 Feb 26. Mol Psychiatry. 2020. PMID: 32099098 Free PMC article.
Genome screen for platelet monoamine oxidase (MAO) activity.
Saccone NL, Rice JP, Rochberg N, Goate A, Reich T, Shears S, Wu W, Nurnberger JI Jr, Foroud T, Edenberg HJ, Li TK. Saccone NL, et al. Am J Med Genet. 1999 Oct 15;88(5):517-21. doi: 10.1002/(sici)1096-8628(19991015)88:5<517::aid-ajmg15>3.0.co;2-b. Am J Med Genet. 1999. PMID: 10490709
A genome screen of maximum number of drinks as an alcoholism phenotype.
Saccone NL, Kwon JM, Corbett J, Goate A, Rochberg N, Edenberg HJ, Foroud T, Li TK, Begleiter H, Reich T, Rice JP. Saccone NL, et al. Am J Med Genet. 2000 Oct 9;96(5):632-7. doi: 10.1002/1096-8628(20001009)96:5<632::aid-ajmg8>3.0.co;2-#. Am J Med Genet. 2000. PMID: 11054770
A clustering approach for localizing disease susceptibility loci.
Neuman RJ, Bierut LJ, Rasmussen E, Saccone NL, Rice JP, Corbett J, Sun L, Liu KY. Neuman RJ, et al. Among authors: saccone nl. Genet Epidemiol. 2001;21 Suppl 1:S534-9. doi: 10.1002/gepi.2001.21.s1.s534. Genet Epidemiol. 2001. PMID: 11793732
Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin.
Wang JC, Hinrichs AL, Bertelsen S, Stock H, Budde JP, Dick DM, Bucholz KK, Rice J, Saccone N, Edenberg HJ, Hesselbrock V, Kuperman S, Schuckit MA, Bierut LJ, Goate AM. Wang JC, et al. Among authors: saccone n. Alcohol Clin Exp Res. 2007 Feb;31(2):209-15. doi: 10.1111/j.1530-0277.2006.00297.x. Alcohol Clin Exp Res. 2007. PMID: 17250611
A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9.
Dick DM, Aliev F, Wang JC, Saccone S, Hinrichs A, Bertelsen S, Budde J, Saccone N, Foroud T, Nurnberger J Jr, Xuei X, Conneally PM, Schuckit M, Almasy L, Crowe R, Kuperman S, Kramer J, Tischfield JA, Hesselbrock V, Edenberg HJ, Porjesz B, Rice JP, Bierut L, Goate A. Dick DM, et al. Among authors: saccone s, saccone n. Biol Psychiatry. 2008 Jun 1;63(11):1047-53. doi: 10.1016/j.biopsych.2007.11.005. Epub 2007 Dec 27. Biol Psychiatry. 2008. PMID: 18163977 Free PMC article.
Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence.
Wang JC, Grucza R, Cruchaga C, Hinrichs AL, Bertelsen S, Budde JP, Fox L, Goldstein E, Reyes O, Saccone N, Saccone S, Xuei X, Bucholz K, Kuperman S, Nurnberger J Jr, Rice JP, Schuckit M, Tischfield J, Hesselbrock V, Porjesz B, Edenberg HJ, Bierut LJ, Goate AM. Wang JC, et al. Among authors: saccone s, saccone n. Mol Psychiatry. 2009 May;14(5):501-10. doi: 10.1038/mp.2008.42. Epub 2008 Apr 15. Mol Psychiatry. 2009. PMID: 18414406 Free PMC article.
147 results