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Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in TH2 cytokine levels.
Schedel M, Michel S, Gaertner VD, Toncheva AA, Depner M, Binia A, Schieck M, Rieger MT, Klopp N, von Berg A, Bufe A, Laub O, Rietschel E, Heinzmann A, Simma B, Vogelberg C, Genuneit J, Illig T, Kabesch M. Schedel M, et al. Among authors: schieck m. J Allergy Clin Immunol. 2015 Oct;136(4):893-903.e14. doi: 10.1016/j.jaci.2015.03.014. Epub 2015 Apr 28. J Allergy Clin Immunol. 2015. PMID: 25930191
Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages.
Schieck M, Schouten JP, Michel S, Suttner K, Toncheva AA, Gaertner VD, Illig T, Lipinski S, Franke A, Klintschar M, Kalayci O, Sahiner UM, Birben E, Melén E, Pershagen G, Freidin MB, Ogorodova LM, Granell R, Henderson J, Brunekreef B, Smit HA, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Genuneit J, Jonigk D, Postma DS, Koppelman GH, Vonk JM, Timens W, Boezen HM, Kabesch M. Schieck M, et al. J Allergy Clin Immunol. 2016 Aug;138(2):421-31. doi: 10.1016/j.jaci.2015.12.1305. Epub 2016 Feb 20. J Allergy Clin Immunol. 2016. PMID: 26906082
Genetic variation in TH17 pathway genes, childhood asthma, and total serum IgE levels.
Schieck M, Michel S, Suttner K, Illig T, Zeilinger S, Franke A, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Frischer T, Genuneit J, Kerzel S, Kabesch M. Schieck M, et al. J Allergy Clin Immunol. 2014 Mar;133(3):888-91. doi: 10.1016/j.jaci.2013.08.048. Epub 2013 Nov 1. J Allergy Clin Immunol. 2014. PMID: 24184148 No abstract available.
Regulation of TH17 markers early in life through maternal farm exposure.
Lluis A, Ballenberger N, Illi S, Schieck M, Kabesch M, Illig T, Schleich I, von Mutius E, Schaub B. Lluis A, et al. Among authors: schieck m. J Allergy Clin Immunol. 2014 Mar;133(3):864-71. doi: 10.1016/j.jaci.2013.09.030. Epub 2013 Nov 23. J Allergy Clin Immunol. 2014. PMID: 24275363
IL-33 polymorphisms are associated with increased risk of hay fever and reduced regulatory T cells in a birth cohort.
Schröder PC, Casaca VI, Illi S, Schieck M, Michel S, Böck A, Roduit C, Frei R, Lluis A, Genuneit J, Pfefferle P, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Lauener R, Vuitton DA, Dalphin JC, Pekkanen J, von Mutius E, Kabesch M, Schaub B; PASTURE Study group. Schröder PC, et al. Among authors: schieck m. Pediatr Allergy Immunol. 2016 Nov;27(7):687-695. doi: 10.1111/pai.12597. Epub 2016 Jul 12. Pediatr Allergy Immunol. 2016. PMID: 27171815
Combined analysis of transcriptomic and genetic data for the identification of loci involved in glucocorticosteroid response in asthma.
Hernandez-Pacheco N, Gorenjak M, Jurgec S, Corrales A, Jorgensen A, Karimi L, Vijverberg SJ, Berce V, Schieck M, Acosta-Herrera M, Kerick M, Samedy-Bates LA, Tavendale R, Villar J, Mukhopadhyay S, Pirmohamed M, Verhamme KMC, Kabesch M, Hawcutt DB, Turner S, Palmer CN, Burchard EG, Maitland-van der Zee AH, Flores C, Potočnik U, Pino-Yanes M; PiCA and SysPharmPedia consortia. Hernandez-Pacheco N, et al. Among authors: schieck m. Allergy. 2021 Apr;76(4):1238-1243. doi: 10.1111/all.14552. Epub 2020 Sep 16. Allergy. 2021. PMID: 32786158 Free PMC article. No abstract available.
33 results