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Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo.
Otterdal K, Portillo A, Astrup E, Ludviksen JK, Schjalm C, Raoult D, Olano JP, Halvorsen B, Oteo JA, Aukrust P, Mollnes TE, Nilsson PH. Otterdal K, et al. Among authors: schjalm c. Clin Microbiol Infect. 2016 Aug;22(8):734.e1-6. doi: 10.1016/j.cmi.2016.05.010. Epub 2016 May 20. Clin Microbiol Infect. 2016. PMID: 27217049 Free article.
Properdin binding to complement activating surfaces depends on initial C3b deposition.
Harboe M, Johnson C, Nymo S, Ekholt K, Schjalm C, Lindstad JK, Pharo A, Hellerud BC, Nilsson Ekdahl K, Mollnes TE, Nilsson PH. Harboe M, et al. Among authors: schjalm c. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E534-E539. doi: 10.1073/pnas.1612385114. Epub 2017 Jan 9. Proc Natl Acad Sci U S A. 2017. PMID: 28069958 Free PMC article.
Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome.
Thomas AM, Schjalm C, Nilsson PH, Lindenskov PHH, Rørtveit R, Solberg R, Saugstad OD, Berglund MM, Strömberg P, Lau C, Espevik T, Jansen JH, Castellheim A, Mollnes TE, Barratt-Due A. Thomas AM, et al. Among authors: schjalm c. Neonatology. 2018;113(4):322-330. doi: 10.1159/000486542. Epub 2018 Feb 27. Neonatology. 2018. PMID: 29486477 Free PMC article.
Complement Activation in 22q11.2 Deletion Syndrome.
Grinde D, Øverland T, Lima K, Schjalm C, Mollnes TE, Abrahamsen TG. Grinde D, et al. Among authors: schjalm c. J Clin Immunol. 2020 Apr;40(3):515-523. doi: 10.1007/s10875-020-00766-x. Epub 2020 Mar 9. J Clin Immunol. 2020. PMID: 32152940 Free PMC article.
The complement component C5 is not responsible for the alternative pathway activity in rabbit erythrocyte hemolytic assays during eculizumab treatment.
van den Heuvel LP, van de Kar NCAJ, Duineveld C, Sarlea A, van der Velden TJAM, Liebrand WTB, van Kraaij S, Schjalm C, Bouwmeester R, Wetzels JFM, Mollnes TE, Volokhina EB. van den Heuvel LP, et al. Among authors: schjalm c. Cell Mol Immunol. 2020 Jun;17(6):653-655. doi: 10.1038/s41423-020-0406-y. Epub 2020 Mar 24. Cell Mol Immunol. 2020. PMID: 32210393 Free PMC article. No abstract available.
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients.
Holter JC, Pischke SE, de Boer E, Lind A, Jenum S, Holten AR, Tonby K, Barratt-Due A, Sokolova M, Schjalm C, Chaban V, Kolderup A, Tran T, Tollefsrud Gjølberg T, Skeie LG, Hesstvedt L, Ormåsen V, Fevang B, Austad C, Müller KE, Fladeby C, Holberg-Petersen M, Halvorsen B, Müller F, Aukrust P, Dudman S, Ueland T, Andersen JT, Lund-Johansen F, Heggelund L, Dyrhol-Riise AM, Mollnes TE. Holter JC, et al. Among authors: schjalm c. Proc Natl Acad Sci U S A. 2020 Oct 6;117(40):25018-25025. doi: 10.1073/pnas.2010540117. Epub 2020 Sep 17. Proc Natl Acad Sci U S A. 2020. PMID: 32943538 Free PMC article.
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19.
Jøntvedt Jørgensen M, Holter JC, Christensen EE, Schjalm C, Tonby K, Pischke SE, Jenum S, Skeie LG, Nur S, Lind A, Opsand H, Enersen TB, Grøndahl R, Hermann A, Dudman S, Muller F, Ueland T, Mollnes TE, Aukrust P, Heggelund L, Holten AR, Dyrhol-Riise AM. Jøntvedt Jørgensen M, et al. Among authors: schjalm c. Sci Rep. 2020 Dec 10;10(1):21697. doi: 10.1038/s41598-020-78710-7. Sci Rep. 2020. PMID: 33303843 Free PMC article. Clinical Trial.
26 results