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A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism.
Mol Cell. 2016 Sep 1;63(5):796-810. doi: 10.1016/j.molcel.2016.07.021. Epub 2016 Aug 25.
Mol Cell. 2016.
PMID: 27570075
Free article.
The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity.
Crippa V, Cicardi ME, Ramesh N, Seguin SJ, Ganassi M, Bigi I, Diacci C, Zelotti E, Baratashvili M, Gregory JM, Dobson CM, Cereda C, Pandey UB, Poletti A, Carra S.
Crippa V, et al. Among authors: seguin sj.
Hum Mol Genet. 2016 Sep 15;25(18):3908-3924. doi: 10.1093/hmg/ddw232. Epub 2016 Jul 27.
Hum Mol Genet. 2016.
PMID: 27466192
Free PMC article.
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Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly.
Seguin SJ, Morelli FF, Vinet J, Amore D, De Biasi S, Poletti A, Rubinsztein DC, Carra S.
Seguin SJ, et al.
Cell Death Differ. 2014 Dec;21(12):1838-51. doi: 10.1038/cdd.2014.103. Epub 2014 Jul 18.
Cell Death Differ. 2014.
PMID: 25034784
Free PMC article.
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HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy.
Carra S, Seguin SJ, Landry J.
Carra S, et al. Among authors: seguin sj.
Autophagy. 2008 Feb;4(2):237-9. doi: 10.4161/auto.5407. Epub 2007 Dec 11.
Autophagy. 2008.
PMID: 18094623
Review.
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HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy.
Carra S, Seguin SJ, Lambert H, Landry J.
Carra S, et al. Among authors: seguin sj.
J Biol Chem. 2008 Jan 18;283(3):1437-1444. doi: 10.1074/jbc.M706304200. Epub 2007 Nov 15.
J Biol Chem. 2008.
PMID: 18006506
Free article.
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Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction.
Fuchs M, Poirier DJ, Seguin SJ, Lambert H, Carra S, Charette SJ, Landry J.
Fuchs M, et al. Among authors: seguin sj.
Biochem J. 2009 Dec 14;425(1):245-55. doi: 10.1042/BJ20090907.
Biochem J. 2009.
PMID: 19845507
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Ancestral T-box mutation is present in many, but not all, short-tailed dog breeds.
Hytönen MK, Grall A, Hédan B, Dréano S, Seguin SJ, Delattre D, Thomas A, Galibert F, Paulin L, Lohi H, Sainio K, André C.
Hytönen MK, et al. Among authors: seguin sj.
J Hered. 2009 Mar-Apr;100(2):236-40. doi: 10.1093/jhered/esn085. Epub 2008 Oct 14.
J Hered. 2009.
PMID: 18854372
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