Shaw RJ - Search Results

1

Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α.

Faubert B, Vincent EE, Griss T, Samborska B, Izreig S, Svensson RU, Mamer OA, Avizonis D, Shackelford DB, Shaw RJ, Jones RG. Faubert B, et al. Among authors: shaw rj. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2554-9. doi: 10.1073/pnas.1312570111. Epub 2014 Feb 3. Proc Natl Acad Sci U S A. 2014. PMID: 24550282 Free PMC article.

2

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.

Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. Shaw RJ, et al. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3329-35. doi: 10.1073/pnas.0308061100. Epub 2004 Feb 25. Proc Natl Acad Sci U S A. 2004. PMID: 14985505 Free PMC article.

3

AMPK phosphorylation of raptor mediates a metabolic checkpoint.

Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. Gwinn DM, et al. Among authors: shaw rj. Mol Cell. 2008 Apr 25;30(2):214-26. doi: 10.1016/j.molcel.2008.03.003. Mol Cell. 2008. PMID: 18439900 Free PMC article.

4

mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome.

Shackelford DB, Vasquez DS, Corbeil J, Wu S, Leblanc M, Wu CL, Vera DR, Shaw RJ. Shackelford DB, et al. Among authors: shaw rj. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11137-42. doi: 10.1073/pnas.0900465106. Epub 2009 Jun 18. Proc Natl Acad Sci U S A. 2009. PMID: 19541609 Free PMC article.

5

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.

Shackelford DB, Shaw RJ. Shackelford DB, et al. Among authors: shaw rj. Nat Rev Cancer. 2009 Aug;9(8):563-75. doi: 10.1038/nrc2676. Nat Rev Cancer. 2009. PMID: 19629071 Free PMC article.

6

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.

Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ. Egan DF, et al. Among authors: shaw rj. Science. 2011 Jan 28;331(6016):456-61. doi: 10.1126/science.1196371. Epub 2010 Dec 23. Science. 2011. PMID: 21205641 Free PMC article.

7

Cancer metabolism: Tumour friend or foe.

Svensson RU, Shaw RJ. Svensson RU, et al. Among authors: shaw rj. Nature. 2012 May 31;485(7400):590-1. doi: 10.1038/485590a. Nature. 2012. PMID: 22660317 No abstract available.

8

LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin.

Shackelford DB, Abt E, Gerken L, Vasquez DS, Seki A, Leblanc M, Wei L, Fishbein MC, Czernin J, Mischel PS, Shaw RJ. Shackelford DB, et al. Among authors: shaw rj. Cancer Cell. 2013 Feb 11;23(2):143-58. doi: 10.1016/j.ccr.2012.12.008. Epub 2013 Jan 24. Cancer Cell. 2013. PMID: 23352126 Free PMC article.

9

An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential.

Goodwin JM, Svensson RU, Lou HJ, Winslow MM, Turk BE, Shaw RJ. Goodwin JM, et al. Among authors: shaw rj. Mol Cell. 2014 Aug 7;55(3):436-50. doi: 10.1016/j.molcel.2014.06.021. Epub 2014 Jul 17. Mol Cell. 2014. PMID: 25042806 Free PMC article.

10

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models.

Svensson RU, Parker SJ, Eichner LJ, Kolar MJ, Wallace M, Brun SN, Lombardo PS, Van Nostrand JL, Hutchins A, Vera L, Gerken L, Greenwood J, Bhat S, Harriman G, Westlin WF, Harwood HJ Jr, Saghatelian A, Kapeller R, Metallo CM, Shaw RJ. Svensson RU, et al. Among authors: shaw rj. Nat Med. 2016 Oct;22(10):1108-1119. doi: 10.1038/nm.4181. Epub 2016 Sep 19. Nat Med. 2016. PMID: 27643638 Free PMC article.

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