Shih TL - Search Results

1

L-770,644: a potent and selective human beta3 adrenergic receptor agonist with improved oral bioavailability.

Shih TL, Candelore MR, Cascieri MA, Chiu SH, Colwell LF Jr, Deng L, Feeney WP, Forrest MJ, Hom GJ, MacIntyre DE, Miller RR, Stearns RA, Strader CD, Tota L, Wyvratt MJ, Fisher MH, Weber AE. Shih TL, et al. Bioorg Med Chem Lett. 1999 May 3;9(9):1251-4. doi: 10.1016/s0960-894x(99)00182-1. Bioorg Med Chem Lett. 1999. PMID: 10340609

2

Side-chain homologation of nodulisporic acid: synthesis of potent new dienyl derivatives.

Ok D, Li C, Shih TL, Salva S, Ayer MB, Colletti SL, Chakravarty PK, Wyvratt MJ, Fisher MH, Gregory L, Zakson-Aiken M, Shoop WL, Schmatz DM, Meinke PT. Ok D, et al. Among authors: shih tl. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1751-4. doi: 10.1016/s0960-894x(02)00284-6. Bioorg Med Chem Lett. 2002. PMID: 12067553

3

Nodulisporic acid side-chain modifications: access to the 2", 3", 4", and 6" registers.

Chakravarty PK, Shih TL, Colletti SL, Ayer MB, Snedden C, Kuo H, Tyagarajan S, Gregory L, Zakson-Aiken M, Shoop WL, Schmatz DM, Wyvratt M, Fisher MH, Meinke PT. Chakravarty PK, et al. Among authors: shih tl. Bioorg Med Chem Lett. 2003 Jan 6;13(1):147-50. doi: 10.1016/s0960-894x(02)00826-0. Bioorg Med Chem Lett. 2003. PMID: 12467636

4

Discovery of the development candidate N-tert-butyl nodulisporamide: a safe and efficacious once monthly oral agent for the control of fleas and ticks on companion animals.

Meinke PT, Colletti SL, Fisher MH, Wyvratt MJ, Shih TL, Ayer MB, Li C, Lim J, Ok D, Salva S, Warmke LM, Zakson M, Michael BF, Demontigny P, Ostlind DA, Fink D, Drag M, Schmatz DM, Shoop WL. Meinke PT, et al. Among authors: shih tl. J Med Chem. 2009 Jun 11;52(11):3505-15. doi: 10.1021/jm801334v. J Med Chem. 2009. PMID: 19445514

5

Beta(3)-adrenoceptor agonist-induced increases in lipolysis, metabolic rate, facial flushing, and reflex tachycardia in anesthetized rhesus monkeys.

Hom GJ, Forrest MJ, Bach TJ, Brady E, Candelore MR, Cascieri MA, Fletcher DJ, Fisher MH, Iliff SA, Mathvink R, Metzger J, Pecore V, Saperstein R, Shih T, Weber AE, Wyvratt M, Zafian P, MacIntyre DE. Hom GJ, et al. J Pharmacol Exp Ther. 2001 Apr;297(1):299-307. J Pharmacol Exp Ther. 2001. PMID: 11259557

6

Chemical modification of nodulisporic acid A: preliminary structure-activity relationships.

Meinke PT, Ayer MB, Colletti SL, Li C, Lim J, Ok D, Salva S, Schmatz DM, Shih TL, Shoop WL, Warmke LM, Wyvratt MJ, Zakson-Aiken M, Fisher MH. Meinke PT, et al. Among authors: shih tl. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2371-4. doi: 10.1016/s0960-894x(00)00469-8. Bioorg Med Chem Lett. 2000. PMID: 11055358

7

Synthesis of side chain truncated 3"-aldehyde, 3"-carboxylic acid, and 1"-aldehyde from nodulisporic acid A.

Chakravarty PK, Tyagarajan S, Shih TL, Salva S, Snedden C, Wyvratt MJ, Fisher MH, Meinke PT. Chakravarty PK, et al. Among authors: shih tl. Org Lett. 2002 Apr 18;4(8):1291-4. doi: 10.1021/ol025766d. Org Lett. 2002. PMID: 11950345

8

Rapid pharmacokinetic screening for the selection of new drug discovery candidates using a generic isocratic liquid chromatography--atmospheric pressure ionization tandem mass spectrometry method.

Colwell LF Jr, Tamvakopoulos CS, Wang PR, Pivnichny JV, Shih TL. Colwell LF Jr, et al. Among authors: shih tl. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 May 25;772(1):89-98. doi: 10.1016/s1570-0232(02)00061-2. J Chromatogr B Analyt Technol Biomed Life Sci. 2002. PMID: 12016019

9

Liquid chromatographic-tandem mass spectrometric urine assay for a highly metabolized cyclic ureidobenzenesulfonamide: issues concerning assay specificity and quality control preparation.

Fisher AL, DePuy E, Shih T, Stearns R, Lee Y, Gottesdiener K, Flattery S, De Smet M, Keymeulen B, Musson DG. Fisher AL, et al. J Pharm Biomed Anal. 2001 Dec;26(5-6):739-52. doi: 10.1016/s0731-7085(01)00438-1. J Pharm Biomed Anal. 2001. PMID: 11600286

10

Synthesis of 2-(pyridylvinyl)chromen-4-ones and their N-oxide analogs for assessment of their biological activities as anticancer agents.

Ding YC, Chu YC, Chang CH, Liang JH, Chen JJ, Shih TL. Ding YC, et al. Among authors: shih tl. Arch Pharm (Weinheim). 2024 Apr;357(4):e2300445. doi: 10.1002/ardp.202300445. Epub 2024 Jan 16. Arch Pharm (Weinheim). 2024. PMID: 38227420

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