Shin JW - Search Results

1

Population-specific genetic modification of Huntington's disease in Venezuela.

Chao MJ, Kim KH, Shin JW, Lucente D, Wheeler VC, Li H, Roach JC, Hood L, Wexler NS, Jardim LB, Holmans P, Jones L, Orth M, Kwak S, MacDonald ME, Gusella JF, Lee JM. Chao MJ, et al. Among authors: shin jw. PLoS Genet. 2018 May 11;14(5):e1007274. doi: 10.1371/journal.pgen.1007274. eCollection 2018 May. PLoS Genet. 2018. PMID: 29750799 Free PMC article.

2

Novel allele-specific quantification methods reveal no effects of adult onset CAG repeats on HTT mRNA and protein levels.

Shin A, Shin B, Shin JW, Kim KH, Atwal RS, Hope JM, Gillis T, Leszyk JD, Shaffer SA, Lee R, Kwak S, MacDonald ME, Gusella JF, Seong IS, Lee JM. Shin A, et al. Among authors: shin b, shin jw. Hum Mol Genet. 2017 Apr 1;26(7):1258-1267. doi: 10.1093/hmg/ddx033. Hum Mol Genet. 2017. PMID: 28165127 Free PMC article.

3

Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9.

Shin JW, Kim KH, Chao MJ, Atwal RS, Gillis T, MacDonald ME, Gusella JF, Lee JM. Shin JW, et al. Hum Mol Genet. 2016 Oct 15;25(20):4566-4576. doi: 10.1093/hmg/ddw286. Hum Mol Genet. 2016. PMID: 28172889 Free PMC article.

4

The prospects of CRISPR-based genome engineering in the treatment of neurodegenerative disorders.

Shin JW, Lee JM. Shin JW, et al. Ther Adv Neurol Disord. 2017 Nov 15;11:1756285617741837. doi: 10.1177/1756285617741837. eCollection 2018. Ther Adv Neurol Disord. 2017. PMID: 29399048 Free PMC article. Review.

5

Full sequence of mutant huntingtin 3'-untranslated region and modulation of its gene regulatory activity by endogenous microRNA.

Kim KH, Abu Elneel K, Shin JW, Keum JW, Seong D, Kwak S, Lee R, Gusella JF, MacDonald ME, Seong IS, Lee JM. Kim KH, et al. Among authors: shin jw. J Hum Genet. 2019 Oct;64(10):995-1004. doi: 10.1038/s10038-019-0639-8. Epub 2019 Jul 11. J Hum Genet. 2019. PMID: 31296921 Free PMC article.

6

Genetic and Functional Analyses Point to FAN1 as the Source of Multiple Huntington Disease Modifier Effects.

Kim KH, Hong EP, Shin JW, Chao MJ, Loupe J, Gillis T, Mysore JS, Holmans P, Jones L, Orth M, Monckton DG, Long JD, Kwak S, Lee R, Gusella JF, MacDonald ME, Lee JM. Kim KH, et al. Among authors: shin jw. Am J Hum Genet. 2020 Jul 2;107(1):96-110. doi: 10.1016/j.ajhg.2020.05.012. Epub 2020 Jun 25. Am J Hum Genet. 2020. PMID: 32589923 Free PMC article.

7

Haplotype-specific insertion-deletion variations for allele-specific targeting in Huntington's disease.

Shin JW, Shin A, Park SS, Lee JM. Shin JW, et al. Among authors: shin a. Mol Ther Methods Clin Dev. 2022 Mar 4;25:84-95. doi: 10.1016/j.omtm.2022.03.001. eCollection 2022 Jun 9. Mol Ther Methods Clin Dev. 2022. PMID: 35356757 Free PMC article.

8

Allele-specific silencing of the gain-of-function mutation in Huntington's disease using CRISPR/Cas9.

Shin JW, Hong EP, Park SS, Choi DE, Seong IS, Whittaker MN, Kleinstiver BP, Chen RZ, Lee JM. Shin JW, et al. JCI Insight. 2022 Oct 10;7(19):e141042. doi: 10.1172/jci.insight.141042. JCI Insight. 2022. PMID: 36040815 Free PMC article.

9

PAM-altering SNP-based allele-specific CRISPR-Cas9 therapeutic strategies for Huntington's disease.

Shin JW, Hong EP, Park SS, Choi DE, Zeng S, Chen RZ, Lee JM. Shin JW, et al. Mol Ther Methods Clin Dev. 2022 Aug 14;26:547-561. doi: 10.1016/j.omtm.2022.08.005. eCollection 2022 Sep 8. Mol Ther Methods Clin Dev. 2022. PMID: 36092363 Free PMC article.

10

Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington's disease.

Choi DE, Shin JW, Zeng S, Hong EP, Jang JH, Loupe JM, Wheeler VC, Stutzman HE, Kleinstiver BP, Lee JM. Choi DE, et al. Among authors: shin jw. bioRxiv [Preprint]. 2023 Apr 28:2023.04.28.538700. doi: 10.1101/2023.04.28.538700. bioRxiv. 2023. PMID: 37162872 Free PMC article. Preprint.

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