Sigmond J - Search Results

1

Pharmacological aspects of the enzastaurin-pemetrexed combination in non-small cell lung cancer (NSCLC).

Giovannetti E, Honeywell R, Hanauske AR, Tekle C, Kuenen B, Sigmond J, Giaccone G, Peters GJ. Giovannetti E, et al. Among authors: sigmond j. Curr Drug Targets. 2010 Jan;11(1):12-28. doi: 10.2174/138945010790031009. Curr Drug Targets. 2010. PMID: 19839931 Review.

2

Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells.

Tekle C, Giovannetti E, Sigmond J, Graff JR, Smid K, Peters GJ. Tekle C, et al. Among authors: sigmond j. Br J Cancer. 2008 Sep 2;99(5):750-9. doi: 10.1038/sj.bjc.6604566. Epub 2008 Aug 19. Br J Cancer. 2008. PMID: 18728666 Free PMC article.

3

Combinations of 5-fluorouracil with UCN-01 or staurosporine.

Sigmond J, Comijn EM, Kamphuis JA, Peters GJ. Sigmond J, et al. Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1503-6. doi: 10.1081/NCN-200027718. Nucleosides Nucleotides Nucleic Acids. 2004. PMID: 15571286

4

Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression.

Sigmond J, Backus HH, Wouters D, Temmink OH, Jansen G, Peters GJ. Sigmond J, et al. Biochem Pharmacol. 2003 Aug 1;66(3):431-8. doi: 10.1016/s0006-2952(03)00287-9. Biochem Pharmacol. 2003. PMID: 12907242

5

Staurosporine increases toxicity of gemcitabine in non-small cell lung cancer cells: role of protein kinase C, deoxycytidine kinase and ribonucleotide reductase.

Sigmond J, Bergman AM, Leon LG, Loves WJ, Hoebe EK, Peters GJ. Sigmond J, et al. Anticancer Drugs. 2010 Jul;21(6):591-9. doi: 10.1097/CAD.0b013e32833a3543. Anticancer Drugs. 2010. PMID: 20436341

6

Immunocytochemical detection of deoxycytidine kinase in haematological malignancies and solid tumours.

Hubeek I, Peters GJ, Broekhuizen AJ, Talianidis I, Sigmond J, Gibson BE, Creutzig U, Giaccone G, Kaspers GJ. Hubeek I, et al. Among authors: sigmond j. J Clin Pathol. 2005 Jul;58(7):695-9. doi: 10.1136/jcp.2004.023861. J Clin Pathol. 2005. PMID: 15976334 Free PMC article.

7

The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent.

Sigmond J, Kamphuis JA, Laan AC, Hoebe EK, Bergman AM, Peters GJ. Sigmond J, et al. Biochem Pharmacol. 2007 May 15;73(10):1548-57. doi: 10.1016/j.bcp.2007.01.025. Epub 2007 Jan 21. Biochem Pharmacol. 2007. PMID: 17324380

8

Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer.

Sigmond J, Honeywell RJ, Postma TJ, Dirven CM, de Lange SM, van der Born K, Laan AC, Baayen JC, Van Groeningen CJ, Bergman AM, Giaccone G, Peters GJ. Sigmond J, et al. Ann Oncol. 2009 Jan;20(1):182-7. doi: 10.1093/annonc/mdn543. Epub 2008 Aug 12. Ann Oncol. 2009. PMID: 18701427 Free article. Clinical Trial.

9

Enhanced activity of deoxycytidine kinase after pulsed low dose rate and single dose gamma irradiation.

Sigmond J, Haveman J, Kreder NC, Loves WJ, van Bree C, Franken NA, Peters GJ. Sigmond J, et al. Nucleosides Nucleotides Nucleic Acids. 2006;25(9-11):1177-80. doi: 10.1080/15257770600894394. Nucleosides Nucleotides Nucleic Acids. 2006. PMID: 17065085

10

Quantitative real time PCR of deoxycytidine kinase mRNA by Light Cycler PCR in relation to enzyme activity and gemcitabine sensitivity.

Sigmond J, Kroep JR, Loves W, Codacci-Pisanelli G, Peters GJ. Sigmond J, et al. Cancer Lett. 2004 Sep 30;213(2):173-9. doi: 10.1016/j.canlet.2004.04.016. Cancer Lett. 2004. PMID: 15327832

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