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RALDH1 Inhibition Shows Immunotherapeutic Efficacy in Hepatocellular Carcinoma.
Yu P, Cao S, Yang SM, Rai G, Martinez NJ, Yasgar A, Zakharov AV, Simeonov A, Molina Arocho WA, Lobel GP, Mohei H, Scott AL, Zhai L, Furth EE, Simon MC, Haldar M. Yu P, et al. Among authors: simeonov a. Cancer Immunol Res. 2024 Feb 2;12(2):180-194. doi: 10.1158/2326-6066.CIR-22-1023. Cancer Immunol Res. 2024. PMID: 38051215
A unique borrelial protein facilitates microbial immune evasion.
Foor SD, Brangulis K, Shakya AK, Rana VS, Bista S, Kitsou C, Ronzetti M, Alreja AB, Linden SB, Altieri AS, Baljinnyam B, Akopjana I, Nelson DC, Simeonov A, Herzberg O, Caimano MJ, Pal U. Foor SD, et al. Among authors: simeonov a. mBio. 2023 Oct 31;14(5):e0213523. doi: 10.1128/mbio.02135-23. Epub 2023 Oct 13. mBio. 2023. PMID: 37830812 Free PMC article.
Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors.
Crawford MC, Tripu DR, Barritt SA, Jing Y, Gallimore D, Kales SC, Bhanu NV, Xiong Y, Fang Y, Butler KAT, LeClair CA, Coussens NP, Simeonov A, Garcia BA, Dibble CC, Meier JL. Crawford MC, et al. Among authors: simeonov a. ACS Chem Biol. 2023 Oct 20;18(10):2249-2258. doi: 10.1021/acschembio.3c00293. Epub 2023 Sep 22. ACS Chem Biol. 2023. PMID: 37737090 Free PMC article.
Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells.
Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT. Ikeda Y, et al. Among authors: simeonov a. Biochem Biophys Res Commun. 2023 Oct 30;679:116-121. doi: 10.1016/j.bbrc.2023.08.050. Epub 2023 Aug 26. Biochem Biophys Res Commun. 2023. PMID: 37683456 Free article.
Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes.
Yan W, Zhong Y, Hu X, Xu T, Zhang Y, Kales S, Qu Y, Talley DC, Baljinnyam B, LeClair CA, Simeonov A, Polster BM, Huang R, Ye Y, Rai G, Henderson MJ, Tao D, Fang S. Yan W, et al. Among authors: simeonov a. Nat Commun. 2023 Aug 9;14(1):4798. doi: 10.1038/s41467-023-40537-x. Nat Commun. 2023. PMID: 37558718 Free PMC article.
High-Throughput Screening to Advance In Vitro Toxicology: Accomplishments, Challenges, and Future Directions.
Lynch C, Sakamuru S, Ooka M, Huang R, Klumpp-Thomas C, Shinn P, Gerhold D, Rossoshek A, Michael S, Casey W, Santillo MF, Fitzpatrick S, Thomas RS, Simeonov A, Xia M. Lynch C, et al. Among authors: simeonov a. Annu Rev Pharmacol Toxicol. 2024 Jan 23;64:191-209. doi: 10.1146/annurev-pharmtox-112122-104310. Epub 2023 Jul 28. Annu Rev Pharmacol Toxicol. 2024. PMID: 37506331 Free PMC article. Review.
381 results