Singleton DC - Search Results

1

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.

Pettersen EO, Ebbesen P, Gieling RG, Williams KJ, Dubois L, Lambin P, Ward C, Meehan J, Kunkler IH, Langdon SP, Ree AH, Flatmark K, Lyng H, Calzada MJ, Peso LD, Landazuri MO, Görlach A, Flamm H, Kieninger J, Urban G, Weltin A, Singleton DC, Haider S, Buffa FM, Harris AL, Scozzafava A, Supuran CT, Moser I, Jobst G, Busk M, Toustrup K, Overgaard J, Alsner J, Pouyssegur J, Chiche J, Mazure N, Marchiq I, Parks S, Ahmed A, Ashcroft M, Pastorekova S, Cao Y, Rouschop KM, Wouters BG, Koritzinsky M, Mujcic H, Cojocari D. Pettersen EO, et al. Among authors: singleton dc. J Enzyme Inhib Med Chem. 2015;30(5):689-721. doi: 10.3109/14756366.2014.966704. Epub 2014 Oct 27. J Enzyme Inhib Med Chem. 2015. PMID: 25347767 Review.

2

Targeting the ATF4 pathway in cancer therapy.

Singleton DC, Harris AL. Singleton DC, et al. Expert Opin Ther Targets. 2012 Dec;16(12):1189-202. doi: 10.1517/14728222.2012.728207. Epub 2012 Sep 26. Expert Opin Ther Targets. 2012. PMID: 23009153 Review.

3

Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia.

Rzymski T, Milani M, Singleton DC, Harris AL. Rzymski T, et al. Among authors: singleton dc. Cell Cycle. 2009 Dec;8(23):3838-47. doi: 10.4161/cc.8.23.10086. Epub 2009 Dec 15. Cell Cycle. 2009. PMID: 19887912 Review.

4

Microenvironmental induced essentiality of autophagy.

Singleton DC, Harris AL. Singleton DC, et al. Clin Cancer Res. 2013 Jun 1;19(11):2791-3. doi: 10.1158/1078-0432.CCR-13-0634. Epub 2013 Apr 23. Clin Cancer Res. 2013. PMID: 23613319 Free PMC article.

5

Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis.

Singleton DC, Rouhi P, Zois CE, Haider S, Li JL, Kessler BM, Cao Y, Harris AL. Singleton DC, et al. Oncogene. 2015 Sep 3;34(36):4713-22. doi: 10.1038/onc.2014.396. Epub 2014 Dec 8. Oncogene. 2015. PMID: 25486436 Free PMC article.

6

Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival.

Pike LR, Singleton DC, Buffa F, Abramczyk O, Phadwal K, Li JL, Simon AK, Murray JT, Harris AL. Pike LR, et al. Among authors: singleton dc. Biochem J. 2013 Jan 15;449(2):389-400. doi: 10.1042/BJ20120972. Biochem J. 2013. PMID: 23078367

7

Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts.

Kumar K, Wigfield S, Gee HE, Devlin CM, Singleton D, Li JL, Buffa F, Huffman M, Sinn AL, Silver J, Turley H, Leek R, Harris AL, Ivan M. Kumar K, et al. J Mol Med (Berl). 2013 Jun;91(6):749-58. doi: 10.1007/s00109-013-0996-2. Epub 2013 Jan 30. J Mol Med (Berl). 2013. PMID: 23361368 Free PMC article.

8

Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth.

McIntyre A, Hulikova A, Ledaki I, Snell C, Singleton D, Steers G, Seden P, Jones D, Bridges E, Wigfield S, Li JL, Russell A, Swietach P, Harris AL. McIntyre A, et al. Cancer Res. 2016 Jul 1;76(13):3744-55. doi: 10.1158/0008-5472.CAN-15-1862. Epub 2016 May 17. Cancer Res. 2016. PMID: 27197160

9

Hypoxia-Activated Prodrugs of PERK Inhibitors.

Liew LP, Singleton DC, Wong WW, Cheng GJ, Jamieson SMF, Hay MP. Liew LP, et al. Among authors: singleton dc. Chem Asian J. 2019 Apr 15;14(8):1238-1248. doi: 10.1002/asia.201801826. Epub 2019 Jan 29. Chem Asian J. 2019. PMID: 30615821

10

Therapeutic targeting of the hypoxic tumour microenvironment.

Singleton DC, Macann A, Wilson WR. Singleton DC, et al. Nat Rev Clin Oncol. 2021 Dec;18(12):751-772. doi: 10.1038/s41571-021-00539-4. Epub 2021 Jul 29. Nat Rev Clin Oncol. 2021. PMID: 34326502 Review.

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