Sinha SC - Search Results

1

Chemically Programmed Bispecific Antibodies in Diabody Format.

Walseng E, Nelson CG, Qi J, Nanna AR, Roush WR, Goswami RK, Sinha SC, Burke TR Jr, Rader C. Walseng E, et al. Among authors: sinha sc. J Biol Chem. 2016 Sep 9;291(37):19661-73. doi: 10.1074/jbc.M116.745588. Epub 2016 Jul 21. J Biol Chem. 2016. PMID: 27445334 Free PMC article.

2

An efficient chemical approach to bispecific antibodies and antibodies of high valency.

Gavrilyuk JI, Wuellner U, Salahuddin S, Goswami RK, Sinha SC, Barbas CF 3rd. Gavrilyuk JI, et al. Among authors: sinha sc. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3716-20. doi: 10.1016/j.bmcl.2009.05.047. Epub 2009 May 18. Bioorg Med Chem Lett. 2009. PMID: 19497743 Free PMC article.

3

Chemically programmed antibodies targeting multiple alpha(v) integrins and their effects on tumor-related functions in vitro.

Goswami RK, Bajjuri KM, Forsyth JS, Das S, Hassenpflug W, Huang ZZ, Lerner RA, Felding-Habermann B, Sinha SC. Goswami RK, et al. Among authors: sinha sc. Bioconjug Chem. 2011 Aug 17;22(8):1535-44. doi: 10.1021/bc2000879. Epub 2011 Aug 1. Bioconjug Chem. 2011. PMID: 21774545 Free PMC article.

4

Chemically Programmed Bispecific Antibody Targeting Legumain Protease and αvβ3 Integrin Mediates Strong Antitumor Effects.

Liu Y, Goswami RK, Liu C, Sinha SC. Liu Y, et al. Among authors: sinha sc. Mol Pharm. 2015 Jul 6;12(7):2544-50. doi: 10.1021/acs.molpharmaceut.5b00257. Epub 2015 Jun 9. Mol Pharm. 2015. PMID: 26024761 Free PMC article.

5

Multiple catalytic aldolase antibodies suitable for chemical programming.

Goswami RK, Huang ZZ, Forsyth JS, Felding-Habermann B, Sinha SC. Goswami RK, et al. Among authors: sinha sc. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3821-4. doi: 10.1016/j.bmcl.2009.04.041. Epub 2009 Apr 18. Bioorg Med Chem Lett. 2009. PMID: 19428247 Free PMC article.

6

Synthesis and evaluation of the aldolase antibody-derived chemical-antibodies targeting α5β1 integrin.

Goswami RK, Liu Y, Liu C, Lerner RA, Sinha SC. Goswami RK, et al. Among authors: sinha sc. Mol Pharm. 2013 Feb 4;10(2):538-43. doi: 10.1021/mp3004463. Epub 2012 Nov 14. Mol Pharm. 2013. PMID: 23102054 Free PMC article.

7

Chemically programmed monoclonal antibodies for cancer therapy: adaptor immunotherapy based on a covalent antibody catalyst.

Rader C, Sinha SC, Popkov M, Lerner RA, Barbas CF 3rd. Rader C, et al. Among authors: sinha sc. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5396-400. doi: 10.1073/pnas.0931308100. Epub 2003 Apr 17. Proc Natl Acad Sci U S A. 2003. PMID: 12702756 Free PMC article.

8

Chemical adaptor immunotherapy: design, synthesis, and evaluation of novel integrin-targeting devices.

Li LS, Rader C, Matsushita M, Das S, Barbas CF 3rd, Lerner RA, Sinha SC. Li LS, et al. Among authors: sinha sc. J Med Chem. 2004 Nov 4;47(23):5630-40. doi: 10.1021/jm049666k. J Med Chem. 2004. PMID: 15509162

9

Synthesis of the next-generation therapeutic antibodies that combine cell targeting and antibody-catalyzed prodrug activation.

Abraham S, Guo F, Li LS, Rader C, Liu C, Barbas CF 3rd, Lerner RA, Sinha SC. Abraham S, et al. Among authors: sinha sc. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5584-9. doi: 10.1073/pnas.0700223104. Epub 2007 Mar 19. Proc Natl Acad Sci U S A. 2007. PMID: 17372220 Free PMC article.

10

Small molecule drug activity in melanoma models may be dramatically enhanced with an antibody effector.

Popkov M, Rader C, Gonzalez B, Sinha SC, Barbas CF 3rd. Popkov M, et al. Among authors: sinha sc. Int J Cancer. 2006 Sep 1;119(5):1194-207. doi: 10.1002/ijc.21924. Int J Cancer. 2006. PMID: 16570283 Free article.

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