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Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as potent inhibitors of nicotinamide phosphoribosyltransferase (Nampt).
Lockman JW, Murphy BR, Zigar DF, Judd WR, Slattum PM, Gao ZH, Ostanin K, Green J, McKinnon R, Terry-Lorenzo RT, Fleischer TC, Boniface JJ, Shenderovich M, Willardsen JA. Lockman JW, et al. J Med Chem. 2010 Dec 23;53(24):8734-46. doi: 10.1021/jm101145b. Epub 2010 Nov 16. J Med Chem. 2010. PMID: 21080724
Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors.
Vijay Kumar D, Hoarau C, Bursavich M, Slattum P, Gerrish D, Yager K, Saunders M, Shenderovich M, Roth BL, McKinnon R, Chan A, Cimbora DM, Bradford C, Reeves L, Patton S, Papac DI, Williams BL, Carlson RO. Vijay Kumar D, et al. Among authors: slattum p. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4377-85. doi: 10.1016/j.bmcl.2012.04.131. Epub 2012 May 5. Bioorg Med Chem Lett. 2012. PMID: 22632936
Caged DNA does not aggregate in high ionic strength solutions.
Trubetskoy VS, Loomis A, Slattum PM, Hagstrom JE, Budker VG, Wolff JA. Trubetskoy VS, et al. Among authors: slattum pm. Bioconjug Chem. 1999 Jul-Aug;10(4):624-8. doi: 10.1021/bc9801530. Bioconjug Chem. 1999. PMID: 10411460
Quantitative assessment of DNA condensation.
Trubetskoy VS, Slattum PM, Hagstrom JE, Wolff JA, Budker VG. Trubetskoy VS, et al. Among authors: slattum pm. Anal Biochem. 1999 Feb 15;267(2):309-13. doi: 10.1006/abio.1998.3032. Anal Biochem. 1999. PMID: 10036135
89 results