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A role for the melanocortin 4 receptor in sexual function.
Van der Ploeg LH, Martin WJ, Howard AD, Nargund RP, Austin CP, Guan X, Drisko J, Cashen D, Sebhat I, Patchett AA, Figueroa DJ, DiLella AG, Connolly BM, Weinberg DH, Tan CP, Palyha OC, Pong SS, MacNeil T, Rosenblum C, Vongs A, Tang R, Yu H, Sailer AW, Fong TM, Huang C, Tota MR, Chang RS, Stearns R, Tamvakopoulos C, Christ G, Drazen DL, Spar BD, Nelson RJ, MacIntyre DE. Van der Ploeg LH, et al. Among authors: spar bd. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11381-6. doi: 10.1073/pnas.172378699. Epub 2002 Aug 9. Proc Natl Acad Sci U S A. 2002. PMID: 12172010 Free PMC article.
Diaryl piperidines as CB1 receptor antagonists.
Scott JD, Li SW, Wang H, Xia Y, Jayne CL, Miller MW, Duffy RA, Boykow GC, Kowalski TJ, Spar BD, Stamford AW, Chackalamannil S, Lachowicz JE, Greenlee WJ. Scott JD, et al. Among authors: spar bd. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1278-83. doi: 10.1016/j.bmcl.2009.11.075. Epub 2009 Nov 20. Bioorg Med Chem Lett. 2010. PMID: 20018510
Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice.
Kowalski TJ, Spar BD, Weig B, Farley C, Cook J, Ghibaudi L, Fried S, O'Neill K, Del Vecchio RA, McBriar M, Guzik H, Clader J, Hawes BE, Hwa J. Kowalski TJ, et al. Among authors: spar bd. Eur J Pharmacol. 2006 Mar 27;535(1-3):182-91. doi: 10.1016/j.ejphar.2006.01.062. Epub 2006 Mar 13. Eur J Pharmacol. 2006. PMID: 16540104
Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas.
McBriar MD, Guzik H, Shapiro S, Paruchova J, Xu R, Palani A, Clader JW, Cox K, Greenlee WJ, Hawes BE, Kowalski TJ, O'neill K, Spar BD, Weig B, Weston DJ, Farley C, Cook J. McBriar MD, et al. Among authors: spar bd. J Med Chem. 2006 Apr 6;49(7):2294-310. doi: 10.1021/jm050886n. J Med Chem. 2006. PMID: 16570926
15 results