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Abnormalities in proinsulin processing in islets from individuals with longstanding T1D.
Sims EK, Syed F, Nyalwidhe J, Bahnson HT, Haataja L, Speake C, Morris MA, Balamurugan AN, Mirmira RG, Nadler J, Mastracci TL, Arvan P, Greenbaum CJ, Evans-Molina C. Sims EK, et al. Among authors: speake c. Transl Res. 2019 Nov;213:90-99. doi: 10.1016/j.trsl.2019.08.001. Epub 2019 Aug 9. Transl Res. 2019. PMID: 31442418 Free PMC article.
Low HERV-K(C4) copy number is associated with type 1 diabetes.
Mason MJ, Speake C, Gersuk VH, Nguyen QA, O'Brien KK, Odegard JM, Buckner JH, Greenbaum CJ, Chaussabel D, Nepom GT. Mason MJ, et al. Among authors: speake c. Diabetes. 2014 May;63(5):1789-95. doi: 10.2337/db13-1382. Epub 2014 Jan 15. Diabetes. 2014. PMID: 24430436
Measurement of Pro-Islet Amyloid Polypeptide (1-48) in Diabetes and Islet Transplants.
Courtade JA, Klimek-Abercrombie AM, Chen YC, Patel N, Lu PYT, Speake C, Orban PC, Najafian B, Meneilly G, Greenbaum CJ, Warnock GL, Panagiotopoulos C, Verchere CB. Courtade JA, et al. Among authors: speake c. J Clin Endocrinol Metab. 2017 Jul 1;102(7):2595-2603. doi: 10.1210/jc.2016-2773. J Clin Endocrinol Metab. 2017. PMID: 28368485
Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes.
Cerosaletti K, Barahmand-Pour-Whitman F, Yang J, DeBerg HA, Dufort MJ, Murray SA, Israelsson E, Speake C, Gersuk VH, Eddy JA, Reijonen H, Greenbaum CJ, Kwok WW, Wambre E, Prlic M, Gottardo R, Nepom GT, Linsley PS. Cerosaletti K, et al. Among authors: speake c. J Immunol. 2017 Jul 1;199(1):323-335. doi: 10.4049/jimmunol.1700172. Epub 2017 May 31. J Immunol. 2017. PMID: 28566371 Free PMC article.
Innate immune activity as a predictor of persistent insulin secretion and association with responsiveness to CTLA4-Ig treatment in recent-onset type 1 diabetes.
Cabrera SM, Engle S, Kaldunski M, Jia S, Geoffrey R, Simpson P, Szabo A, Speake C, Greenbaum CJ; Type 1 Diabetes TrialNet CTLA4-Ig (Abatacept) Study Group; Chen YG, Hessner MJ. Cabrera SM, et al. Among authors: speake c. Diabetologia. 2018 Nov;61(11):2356-2370. doi: 10.1007/s00125-018-4708-x. Epub 2018 Aug 30. Diabetologia. 2018. PMID: 30167736 Free PMC article.
129 results