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Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis.
Pilely K, Rosbjerg A, Genster N, Gal P, Pál G, Halvorsen B, Holm S, Aukrust P, Bakke SS, Sporsheim B, Nervik I, Niyonzima N, Bartels ED, Stahl GL, Mollnes TE, Espevik T, Garred P. Pilely K, et al. Among authors: sporsheim b. J Immunol. 2016 Jun 15;196(12):5064-74. doi: 10.4049/jimmunol.1502595. Epub 2016 May 16. J Immunol. 2016. PMID: 27183610
Increased expression of TFPI in human carotid stenosis.
Stavik B, Holm S, Espada S, Iversen N, Sporsheim B, Bjerkeli V, Dahl TB, Sandset PM, Skjelland M, Espevik T, Skretting G, Halvorsen B. Stavik B, et al. Among authors: sporsheim b. Thromb Res. 2017 Jul;155:31-37. doi: 10.1016/j.thromres.2017.04.024. Epub 2017 Apr 28. Thromb Res. 2017. PMID: 28482260
Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages.
Lunde NN, Gregersen I, Ueland T, Shetelig C, Holm S, Kong XY, Michelsen AE, Otterdal K, Yndestad A, Broch K, Gullestad L, Nyman TA, Bendz B, Eritsland J, Hoffmann P, Skagen K, Gonçalves I, Nilsson J, Grenegård M, Poreba M, Drag M, Seljeflot I, Sporsheim B, Espevik T, Skjelland M, Johansen HT, Solberg R, Aukrust P, Björkbacka H, Andersen GØ, Halvorsen B. Lunde NN, et al. Among authors: sporsheim b. Atherosclerosis. 2020 Mar;296:74-82. doi: 10.1016/j.atherosclerosis.2019.12.008. Epub 2019 Dec 14. Atherosclerosis. 2020. PMID: 31870625 Free article.
Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis.
Niyonzima N, Bakke SS, Gregersen I, Holm S, Sandanger Ø, Orrem HL, Sporsheim B, Ryan L, Kong XY, Dahl TB, Skjelland M, Sørensen KK, Rokstad AM, Yndestad A, Latz E, Gullestad L, Andersen GØ, Damås JK, Aukrust P, Mollnes TE, Halvorsen B, Espevik T. Niyonzima N, et al. Among authors: sporsheim b. EBioMedicine. 2020 Oct;60:102985. doi: 10.1016/j.ebiom.2020.102985. Epub 2020 Sep 11. EBioMedicine. 2020. PMID: 32927275 Free PMC article.
Patient Derived Colonoids as Drug Testing Platforms-Critical Importance of Oxygen Concentration.
Skovdahl HK, Gopalakrishnan S, Svendsen TD, Granlund AVB, Bakke I, Ginbot ZG, Thorsvik S, Flatberg A, Sporsheim B, Ostrop J, Mollnes TE, Sandvik AK, Bruland T. Skovdahl HK, et al. Among authors: sporsheim b. Front Pharmacol. 2021 May 13;12:679741. doi: 10.3389/fphar.2021.679741. eCollection 2021. Front Pharmacol. 2021. PMID: 34054553 Free PMC article.
Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation.
Niyonzima N, Rahman J, Kunz N, West EE, Freiwald T, Desai JV, Merle NS, Gidon A, Sporsheim B, Lionakis MS, Evensen K, Lindberg B, Skagen K, Skjelland M, Singh P, Haug M, Ruseva MM, Kolev M, Bibby J, Marshall O, O'Brien B, Deeks N, Afzali B, Clark RJ, Woodruff TM, Pryor M, Yang ZH, Remaley AT, Mollnes TE, Hewitt SM, Yan B, Kazemian M, Kiss MG, Binder CJ, Halvorsen B, Espevik T, Kemper C. Niyonzima N, et al. Among authors: sporsheim b. Sci Immunol. 2021 Dec 24;6(66):eabf2489. doi: 10.1126/sciimmunol.abf2489. Epub 2021 Dec 24. Sci Immunol. 2021. PMID: 34932384 Free PMC article.
20 results