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On the perplexingly low rate of transport of IgG2 across the human placenta.
PLoS One. 2014 Sep 24;9(9):e108319. doi: 10.1371/journal.pone.0108319. eCollection 2014.
PLoS One. 2014.
PMID: 25251461
Free PMC article.
Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential.
Stapleton NM, Andersen JT, Stemerding AM, Bjarnarson SP, Verheul RC, Gerritsen J, Zhao Y, Kleijer M, Sandlie I, de Haas M, Jonsdottir I, van der Schoot CE, Vidarsson G.
Stapleton NM, et al.
Nat Commun. 2011 Dec 20;2:599. doi: 10.1038/ncomms1608.
Nat Commun. 2011.
PMID: 22186895
Free PMC article.
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The multiple facets of FcRn in immunity.
Stapleton NM, Einarsdóttir HK, Stemerding AM, Vidarsson G.
Stapleton NM, et al.
Immunol Rev. 2015 Nov;268(1):253-68. doi: 10.1111/imr.12331.
Immunol Rev. 2015.
PMID: 26497526
Review.
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Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental transport.
Stapleton NM, Armstrong-Fisher SS, Andersen JT, van der Schoot CE, Porter C, Page KR, Falconer D, de Haas M, Williamson LM, Clark MR, Vidarsson G, Armour KL.
Stapleton NM, et al.
Mol Immunol. 2018 Mar;95:1-9. doi: 10.1016/j.molimm.2018.01.006. Epub 2018 Feb 20.
Mol Immunol. 2018.
PMID: 29367080
Free article.
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Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge.
Stapleton NM, Brinkhaus M, Armour KL, Bentlage AEH, de Taeye SW, Temming AR, Mok JY, Brasser G, Maas M, van Esch WJE, Clark MR, Williamson LM, van der Schoot CE, Vidarsson G.
Stapleton NM, et al.
Sci Rep. 2019 May 14;9(1):7363. doi: 10.1038/s41598-019-40731-2.
Sci Rep. 2019.
PMID: 31089170
Free PMC article.
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FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis.
Vidarsson G, Stemerding AM, Stapleton NM, Spliethoff SE, Janssen H, Rebers FE, de Haas M, van de Winkel JG.
Vidarsson G, et al. Among authors: stapleton nm.
Blood. 2006 Nov 15;108(10):3573-9. doi: 10.1182/blood-2006-05-024539. Epub 2006 Jul 18.
Blood. 2006.
PMID: 16849638
Free article.
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