Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex.
Staker BL, Feese MD, Cushman M, Pommier Y, Zembower D, Stewart L, Burgin AB.
Staker BL, et al. Among authors: stewart l.
J Med Chem. 2005 Apr 7;48(7):2336-45. doi: 10.1021/jm049146p.
J Med Chem. 2005.
PMID: 15801827
Chem 1985, 260, 14873-14878. Champoux, J. J. Annu. Rev. Biochem. 2001, 70, 369-413. Stewart, L.; et al. Science 1998, 729, 1534-1541.) We report the X-ray crystal structures of the human top1-DNA complex bound with camptothecin and representative members of the inde …
Chem 1985, 260, 14873-14878. Champoux, J. J. Annu. Rev. Biochem. 2001, 70, 369-413. Stewart, L.; et al. Science 1998, 729, 153 …