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Abnormalities in proinsulin processing in islets from individuals with longstanding T1D.
Sims EK, Syed F, Nyalwidhe J, Bahnson HT, Haataja L, Speake C, Morris MA, Balamurugan AN, Mirmira RG, Nadler J, Mastracci TL, Arvan P, Greenbaum CJ, Evans-Molina C. Sims EK, et al. Among authors: syed f. Transl Res. 2019 Nov;213:90-99. doi: 10.1016/j.trsl.2019.08.001. Epub 2019 Aug 9. Transl Res. 2019. PMID: 31442418 Free PMC article.
Biomarkers of β-Cell Stress and Death in Type 1 Diabetes.
Mirmira RG, Sims EK, Syed F, Evans-Molina C. Mirmira RG, et al. Among authors: syed f. Curr Diab Rep. 2016 Oct;16(10):95. doi: 10.1007/s11892-016-0783-x. Curr Diab Rep. 2016. PMID: 27541297 Free PMC article. Review.
Episodic β-cell death and dedifferentiation during diet-induced obesity and dysglycemia in male mice.
Tersey SA, Levasseur EM, Syed F, Farb TB, Orr KS, Nelson JB, Shaw JL, Bokvist K, Mather KJ, Mirmira RG. Tersey SA, et al. Among authors: syed f. FASEB J. 2018 May 29;32(11):fj201800150RR. doi: 10.1096/fj.201800150RR. Online ahead of print. FASEB J. 2018. PMID: 29812970 Free PMC article.
In conclusion, early episodic beta-cell death may be a feature of cellular turnover correlated with changes in glycemia during beta-cell mass accrual in obesity, whereas beta-cell dedifferentiation may be a feature seen later in established disease.-Tersey, S. A., Levasseur, E. M …
In conclusion, early episodic beta-cell death may be a feature of cellular turnover correlated with changes in glycemia during beta-cell mas …
Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.
Levasseur EM, Yamada K, Piñeros AR, Wu W, Syed F, Orr KS, Anderson-Baucum E, Mastracci TL, Maier B, Mosley AL, Liu Y, Bernal-Mizrachi E, Alonso LC, Scott D, Garcia-Ocaña A, Tersey SA, Mirmira RG. Levasseur EM, et al. Among authors: syed f. Sci Signal. 2019 Dec 3;12(610):eaax0715. doi: 10.1126/scisignal.aax0715. Sci Signal. 2019. PMID: 31796630 Free PMC article.
Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention.
Nakayasu ES, Syed F, Tersey SA, Gritsenko MA, Mitchell HD, Chan CY, Dirice E, Turatsinze JV, Cui Y, Kulkarni RN, Eizirik DL, Qian WJ, Webb-Robertson BM, Evans-Molina C, Mirmira RG, Metz TO. Nakayasu ES, et al. Among authors: syed f. Cell Metab. 2020 Feb 4;31(2):363-374.e6. doi: 10.1016/j.cmet.2019.12.005. Epub 2020 Jan 9. Cell Metab. 2020. PMID: 31928885 Free PMC article.
450 results