These A - Search Results

1

Differences in metabolism of the marine biotoxin okadaic acid by human and rat cytochrome P450 monooxygenases.

Kolrep F, Hessel S, These A, Ehlers A, Rein K, Lampen A. Kolrep F, et al. Among authors: these a. Arch Toxicol. 2016 Aug;90(8):2025-36. doi: 10.1007/s00204-015-1591-9. Epub 2015 Sep 15. Arch Toxicol. 2016. PMID: 26374342

2

Sensitive method for the determination of lipophilic marine biotoxins in extracts of mussels and processed shellfish by high-performance liquid chromatography-tandem mass spectrometry based on enrichment by solid-phase extraction.

These A, Scholz J, Preiss-Weigert A. These A, et al. J Chromatogr A. 2009 May 22;1216(21):4529-38. doi: 10.1016/j.chroma.2009.03.062. Epub 2009 Mar 27. J Chromatogr A. 2009. PMID: 19362722

3

Analysis of the passage of the marine biotoxin okadaic acid through an in vitro human gut barrier.

Ehlers A, Scholz J, These A, Hessel S, Preiss-Weigert A, Lampen A. Ehlers A, et al. Among authors: these a. Toxicology. 2011 Jan 11;279(1-3):196-202. doi: 10.1016/j.tox.2010.11.001. Epub 2010 Nov 17. Toxicology. 2011. PMID: 21093526

4

Results of a European interlaboratory method validation study for the quantitative determination of lipophilic marine biotoxins in raw and cooked shellfish based on high-performance liquid chromatography-tandem mass spectrometry. Part I: collaborative study.

These A, Klemm C, Nausch I, Uhlig S. These A, et al. Anal Bioanal Chem. 2011 Jan;399(3):1245-56. doi: 10.1007/s00216-010-4383-3. Epub 2010 Nov 25. Anal Bioanal Chem. 2011. PMID: 21107979

5

Active elimination of the marine biotoxin okadaic acid by P-glycoprotein through an in vitro gastrointestinal barrier.

Ehlers A, These A, Hessel S, Preiss-Weigert A, Lampen A. Ehlers A, et al. Among authors: these a. Toxicol Lett. 2014 Mar 3;225(2):311-7. doi: 10.1016/j.toxlet.2013.12.019. Epub 2013 Dec 25. Toxicol Lett. 2014. PMID: 24374049

6

Structure-activity relationship in the passage of different pyrrolizidine alkaloids through the gastrointestinal barrier: ABCB1 excretes heliotrine and echimidine.

Hessel S, Gottschalk C, Schumann D, These A, Preiss-Weigert A, Lampen A. Hessel S, et al. Among authors: these a. Mol Nutr Food Res. 2014 May;58(5):995-1004. doi: 10.1002/mnfr.201300707. Epub 2013 Dec 27. Mol Nutr Food Res. 2014. PMID: 24375927

7

In vitro biotransformation of pyrrolizidine alkaloids in different species. Part I: Microsomal degradation.

Kolrep F, Numata J, Kneuer C, Preiss-Weigert A, Lahrssen-Wiederholt M, Schrenk D, These A. Kolrep F, et al. Among authors: these a. Arch Toxicol. 2018 Mar;92(3):1089-1097. doi: 10.1007/s00204-017-2114-7. Epub 2017 Nov 16. Arch Toxicol. 2018. PMID: 29143854 Free PMC article.

8

Human CYP3A4-mediated toxification of the pyrrolizidine alkaloid lasiocarpine.

Ebmeyer J, Braeuning A, Glatt H, These A, Hessel-Pras S, Lampen A. Ebmeyer J, et al. Among authors: these a. Food Chem Toxicol. 2019 Aug;130:79-88. doi: 10.1016/j.fct.2019.05.019. Epub 2019 May 16. Food Chem Toxicol. 2019. PMID: 31103741

9

In vitro biotransformation of pyrrolizidine alkaloids in different species: part II-identification and quantitative assessment of the metabolite profile of six structurally different pyrrolizidine alkaloids.

Geburek I, Schrenk D, These A. Geburek I, et al. Among authors: these a. Arch Toxicol. 2020 Nov;94(11):3759-3774. doi: 10.1007/s00204-020-02853-9. Epub 2020 Sep 3. Arch Toxicol. 2020. PMID: 32880719 Free PMC article.

In addition, all diester PAs formed several dehydrogenation products, via the insertion of a second double bond in the necine base, including the formation of glutathione conjugates. In rat liver microsomes, all investigated PAs formed dehydropyrrolizidine metabolites with …

In addition, all diester PAs formed several dehydrogenation products, via the insertion of a second double bond in the necine base, i …

10

Metabolic Pattern of Hepatotoxic Pyrrolizidine Alkaloids in Liver Cells.

Geburek I, Rutz L, Gao L, Küpper JH, These A, Schrenk D. Geburek I, et al. Among authors: these a. Chem Res Toxicol. 2021 Apr 19;34(4):1101-1113. doi: 10.1021/acs.chemrestox.0c00507. Epub 2021 Mar 10. Chem Res Toxicol. 2021. PMID: 33719395

Contamination with 1,2-unsaturated pyrrolizidine alkaloids (PAs) is a serious problem for certain phytomedicines, foods, and animal feeds. ...Our data are in agreement with previously published cyto- and genotoxicity findings and suggests that the metabolic pattern may con …

Contamination with 1,2-unsaturated pyrrolizidine alkaloids (PAs) is a serious problem for certain phytomedicines, foods, and animal f …

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