Thornberry NA - Search Results

1

Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.

Casciola-Rosen L, Garcia-Calvo M, Bull HG, Becker JW, Hines T, Thornberry NA, Rosen A. Casciola-Rosen L, et al. Among authors: thornberry na. J Biol Chem. 2007 Feb 16;282(7):4545-4552. doi: 10.1074/jbc.M606564200. Epub 2006 Dec 19. J Biol Chem. 2007. PMID: 17179148 Free article.

2

Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis.

Willoughby CA, Bull HG, Garcia-Calvo M, Jiang J, Chapman KT, Thornberry NA. Willoughby CA, et al. Among authors: thornberry na. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2197-200. doi: 10.1016/s0960-894x(02)00363-3. Bioorg Med Chem Lett. 2002. PMID: 12127536

3

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis.

Thornberry NA, Rano TA, Peterson EP, Rasper DM, Timkey T, Garcia-Calvo M, Houtzager VM, Nordstrom PA, Roy S, Vaillancourt JP, Chapman KT, Nicholson DW. Thornberry NA, et al. J Biol Chem. 1997 Jul 18;272(29):17907-11. doi: 10.1074/jbc.272.29.17907. J Biol Chem. 1997. PMID: 9218414 Free article.

4

The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1.

Rotonda J, Garcia-Calvo M, Bull HG, Geissler WM, McKeever BM, Willoughby CA, Thornberry NA, Becker JW. Rotonda J, et al. Among authors: thornberry na. Chem Biol. 2001 Apr;8(4):357-68. doi: 10.1016/s1074-5521(01)00018-7. Chem Biol. 2001. PMID: 11325591

5

Adenovirus L4-100K assembly protein is a granzyme B substrate that potently inhibits granzyme B-mediated cell death.

Andrade F, Bull HG, Thornberry NA, Ketner GW, Casciola-Rosen LA, Rosen A. Andrade F, et al. Among authors: thornberry na. Immunity. 2001 Jun;14(6):751-61. doi: 10.1016/s1074-7613(01)00149-2. Immunity. 2001. PMID: 11420045 Free article.

6

Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis.

Andrade F, Roy S, Nicholson D, Thornberry N, Rosen A, Casciola-Rosen L. Andrade F, et al. Immunity. 1998 Apr;8(4):451-60. doi: 10.1016/s1074-7613(00)80550-6. Immunity. 1998. PMID: 9586635 Free article.

7

The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.

Kisselev AF, Garcia-Calvo M, Overkleeft HS, Peterson E, Pennington MW, Ploegh HL, Thornberry NA, Goldberg AL. Kisselev AF, et al. Among authors: thornberry na. J Biol Chem. 2003 Sep 19;278(38):35869-77. doi: 10.1074/jbc.M303725200. Epub 2003 Jun 18. J Biol Chem. 2003. PMID: 12815064 Free article.

8

A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE).

Rano TA, Timkey T, Peterson EP, Rotonda J, Nicholson DW, Becker JW, Chapman KT, Thornberry NA. Rano TA, et al. Among authors: thornberry na. Chem Biol. 1997 Feb;4(2):149-55. doi: 10.1016/s1074-5521(97)90258-1. Chem Biol. 1997. PMID: 9190289

9

Caspase-mediated proteolysis during apoptosis: insights from apoptotic neutrophils.

Sanghavi DM, Thelen M, Thornberry NA, Casciola-Rosen L, Rosen A. Sanghavi DM, et al. Among authors: thornberry na. FEBS Lett. 1998 Jan 30;422(2):179-84. doi: 10.1016/s0014-5793(98)00004-0. FEBS Lett. 1998. PMID: 9490001 Free article.

10

Inhibition of human caspases by peptide-based and macromolecular inhibitors.

Garcia-Calvo M, Peterson EP, Leiting B, Ruel R, Nicholson DW, Thornberry NA. Garcia-Calvo M, et al. Among authors: thornberry na. J Biol Chem. 1998 Dec 4;273(49):32608-13. doi: 10.1074/jbc.273.49.32608. J Biol Chem. 1998. PMID: 9829999 Free article.

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