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Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4 -[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide.
J Med Chem. 2000 Oct 19;43(21):3832-6. doi: 10.1021/jm000286i.
J Med Chem. 2000.
PMID: 11052788
Potent, selective 3-pyridylethanolamine beta3 adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore.
Mathvink RJ, Tolman JS, Chitty D, Candelore MR, Cascieri MA, Colwell LF Jr, Deng L, Feeney WP, Forrest MJ, Hom GJ, MacIntyre DE, Tota L, Wyvratt MJ, Fisher MH, Weber AE.
Mathvink RJ, et al. Among authors: tolman js.
Bioorg Med Chem Lett. 2000 Sep 4;10(17):1971-3. doi: 10.1016/s0960-894x(00)00390-5.
Bioorg Med Chem Lett. 2000.
PMID: 10987429
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Oxidative stress increases ubiquitin--protein conjugates in synaptosomes.
Ramanathan M, Hassanain M, Levitt M, Seth A, Tolman JS, Fried VA, Ingoglia NA.
Ramanathan M, et al. Among authors: tolman js.
Neuroreport. 1999 Dec 16;10(18):3797-802. doi: 10.1097/00001756-199912160-00014.
Neuroreport. 1999.
PMID: 10716212
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Burkholderia cenocepacia type VI secretion system mediates escape of type II secreted proteins into the cytoplasm of infected macrophages.
Rosales-Reyes R, Aubert DF, Tolman JS, Amer AO, Valvano MA.
Rosales-Reyes R, et al. Among authors: tolman js.
PLoS One. 2012;7(7):e41726. doi: 10.1371/journal.pone.0041726. Epub 2012 Jul 25.
PLoS One. 2012.
PMID: 22848580
Free PMC article.
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Global changes in gene expression by the opportunistic pathogen Burkholderia cenocepacia in response to internalization by murine macrophages.
Tolman JS, Valvano MA.
Tolman JS, et al.
BMC Genomics. 2012 Feb 9;13:63. doi: 10.1186/1471-2164-13-63.
BMC Genomics. 2012.
PMID: 22321740
Free PMC article.
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