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An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci.
Logue MW, Miller MW, Wolf EJ, Huber BR, Morrison FG, Zhou Z, Zheng Y, Smith AK, Daskalakis NP, Ratanatharathorn A, Uddin M, Nievergelt CM, Ashley-Koch AE, Baker DG, Beckham JC, Garrett ME, Boks MP, Geuze E, Grant GA, Hauser MA, Kessler RC, Kimbrel NA, Maihofer AX, Marx CE, Qin XJ, Risbrough VB, Rutten BPF, Stein MB, Ursano RJ, Vermetten E, Vinkers CH, Ware EB, Stone A, Schichman SA, McGlinchey RE, Milberg WP, Hayes JP, Verfaellie M; Traumatic Stress Brain Study Group. Logue MW, et al. Clin Epigenetics. 2020 Mar 14;12(1):46. doi: 10.1186/s13148-020-0820-0. Clin Epigenetics. 2020. PMID: 32171335 Free PMC article.
PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies.
Bhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ; Traumatic Stress Brain Study Group; Duman RS, Carson RE, Krystal JH, Pietrzak RH, Cosgrove KP. Bhatt S, et al. Nat Commun. 2020 May 12;11(1):2360. doi: 10.1038/s41467-020-15930-5. Nat Commun. 2020. PMID: 32398677 Free PMC article.
Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence.
Holmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I; Traumatic Stress Brain Study Group. Holmes SE, et al. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8390-8395. doi: 10.1073/pnas.1701749114. Epub 2017 Jul 17. Proc Natl Acad Sci U S A. 2017. PMID: 28716937 Free PMC article.
Reduced interleukin 1A gene expression in the dorsolateral prefrontal cortex of individuals with PTSD and depression.
Morrison FG, Miller MW, Wolf EJ, Logue MW, Maniates H, Kwasnik D, Cherry JD, Svirsky S, Restaino A, Hildebrandt A, Aytan N, Stein TD, Alvarez VE, McKee AC; Traumatic Stress Brain Study Group; Huber BR. Morrison FG, et al. Neurosci Lett. 2019 Jan 23;692:204-209. doi: 10.1016/j.neulet.2018.10.027. Epub 2018 Oct 23. Neurosci Lett. 2019. PMID: 30366016 Free PMC article.
Dysregulated mitochondrial genes and networks with drug targets in postmortem brain of patients with posttraumatic stress disorder (PTSD) revealed by human mitochondria-focused cDNA microarrays.
Su YA, Wu J, Zhang L, Zhang Q, Su DM, He P, Wang BD, Li H, Webster MJ; Traumatic Stress Brain Study Group; Rennert OM, Ursano RJ. Su YA, et al. Int J Biol Sci. 2008 Aug 5;4(4):223-35. doi: 10.7150/ijbs.4.223. Int J Biol Sci. 2008. PMID: 18690294 Free PMC article.