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Page 1
N-benzylpyroglutamyl-L-phenylalanine derivatives as VCAM/VLA-4 antagonists.
Chen L, Tilley JW, Guthrie RW, Mennona F, Huang TN, Kaplan G, Trilles R, Miklowski D, Huby N, Schwinge V, Wolitzky B, Rowan K. Chen L, et al. Among authors: trilles r. Bioorg Med Chem Lett. 2000 Apr 17;10(8):729-33. doi: 10.1016/s0960-894x(00)00089-5. Bioorg Med Chem Lett. 2000. PMID: 10782674
N-acyl phenylalanine analogues as potent small molecule VLA-4 antagonists.
Chen L, Tilley JW, Huang TN, Miklowski D, Trilles R, Guthrie RW, Luk K, Hanglow A, Rowan K, Schwinge V, Wolitzky B. Chen L, et al. Among authors: trilles r. Bioorg Med Chem Lett. 2000 Apr 17;10(8):725-7. doi: 10.1016/s0960-894x(00)00088-3. Bioorg Med Chem Lett. 2000. PMID: 10782673
N-benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors.
Atkinson KA, Beretta EE, Brown JA, Castrodad M, Chen Y, Cosgrove JM, Du P, Litchfield J, Makowski M, Martin K, McLellan TJ, Neagu C, Perry DA, Piotrowski DW, Steppan CM, Trilles R. Atkinson KA, et al. Among authors: trilles r. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1621-5. doi: 10.1016/j.bmcl.2011.01.113. Epub 2011 Jan 31. Bioorg Med Chem Lett. 2011. PMID: 21324691
Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists.
Cameron KO, Beretta EE, Chen Y, Chu-Moyer M, Fernando D, Gao H, Kohrt J, Lavergne S, Jardine Pda S, Guzman-Perez A, Hoth C, Perry DA, Hadcock JR, Gautreau D, Makowski M, Perez S, Polivkova J, Rogers L, Scott DO, Swick AG, Thiede L, Trebino CE, Trilles RV, Wilmowski J, Zhang Y. Cameron KO, et al. Among authors: trilles rv. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2943-7. doi: 10.1016/j.bmcl.2012.02.049. Epub 2012 Feb 23. Bioorg Med Chem Lett. 2012. PMID: 22424974
Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity.
Marcyk PT, LeBlanc EV, Kuntz DA, Xue A, Ortiz F, Trilles R, Bengtson S, Kenney TMG, Huang DS, Robbins N, Williams NS, Krysan DJ, Privé GG, Whitesell L, Cowen LE, Brown LE. Marcyk PT, et al. Among authors: trilles r. J Med Chem. 2021 Jan 28;64(2):1139-1169. doi: 10.1021/acs.jmedchem.0c01777. Epub 2021 Jan 14. J Med Chem. 2021. PMID: 33444025 Free PMC article.
Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1.
Trilles R, Beglov D, Chen Q, He H, Wireman R, Reed A, Chennamadhavuni S, Panek JS, Brown LE, Vajda S, Porco JA Jr, Kelley MR, Georgiadis MM. Trilles R, et al. J Med Chem. 2019 Feb 28;62(4):1971-1988. doi: 10.1021/acs.jmedchem.8b01529. Epub 2019 Feb 6. J Med Chem. 2019. PMID: 30653918 Free PMC article.
Discovery of new antimalarial chemotypes through chemical methodology and library development.
Brown LE, Chih-Chien Cheng K, Wei WG, Yuan P, Dai P, Trilles R, Ni F, Yuan J, MacArthur R, Guha R, Johnson RL, Su XZ, Dominguez MM, Snyder JK, Beeler AB, Schaus SE, Inglese J, Porco JA Jr. Brown LE, et al. Among authors: trilles r. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6775-80. doi: 10.1073/pnas.1017666108. Epub 2011 Apr 15. Proc Natl Acad Sci U S A. 2011. PMID: 21498685 Free PMC article.
16 results