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Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis.
Anisimov A, Tvorogov D, Alitalo A, Leppänen VM, An Y, Han EC, Orsenigo F, Gaál EI, Holopainen T, Koh YJ, Tammela T, Korpisalo P, Keskitalo S, Jeltsch M, Ylä-Herttuala S, Dejana E, Koh GY, Choi C, Saharinen P, Alitalo K. Anisimov A, et al. Among authors: tvorogov d. Circulation. 2013 Jan 29;127(4):424-34. doi: 10.1161/CIRCULATIONAHA.112.127472. Circulation. 2013. PMID: 23357661
Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth.
Holopainen T, López-Alpuche V, Zheng W, Heljasvaara R, Jones D, He Y, Tvorogov D, D'Amico G, Wiener Z, Andersson LC, Pihlajaniemi T, Min W, Alitalo K. Holopainen T, et al. Among authors: d amico g, tvorogov d. Cancer Res. 2012 Jul 15;72(14):3512-21. doi: 10.1158/0008-5472.CAN-11-1070. Epub 2012 May 16. Cancer Res. 2012. PMID: 22593188
Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation.
Leppänen VM, Tvorogov D, Kisko K, Prota AE, Jeltsch M, Anisimov A, Markovic-Mueller S, Stuttfeld E, Goldie KN, Ballmer-Hofer K, Alitalo K. Leppänen VM, et al. Among authors: tvorogov d. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):12960-5. doi: 10.1073/pnas.1301415110. Epub 2013 Jul 22. Proc Natl Acad Sci U S A. 2013. PMID: 23878260 Free PMC article.
Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization.
Tvorogov D, Anisimov A, Zheng W, Leppänen VM, Tammela T, Laurinavicius S, Holnthoner W, Heloterä H, Holopainen T, Jeltsch M, Kalkkinen N, Lankinen H, Ojala PM, Alitalo K. Tvorogov D, et al. Cancer Cell. 2010 Dec 14;18(6):630-40. doi: 10.1016/j.ccr.2010.11.001. Epub 2010 Dec 2. Cancer Cell. 2010. PMID: 21130043 Free article.
Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling.
Holopainen T, Räsänen M, Anisimov A, Tuomainen T, Zheng W, Tvorogov D, Hulmi JJ, Andersson LC, Cenni B, Tavi P, Mervaala E, Kivelä R, Alitalo K. Holopainen T, et al. Among authors: tvorogov d. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13063-8. doi: 10.1073/pnas.1517810112. Epub 2015 Oct 1. Proc Natl Acad Sci U S A. 2015. PMID: 26430242 Free PMC article.
VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.
Tammela T, Zarkada G, Nurmi H, Jakobsson L, Heinolainen K, Tvorogov D, Zheng W, Franco CA, Murtomäki A, Aranda E, Miura N, Ylä-Herttuala S, Fruttiger M, Mäkinen T, Eichmann A, Pollard JW, Gerhardt H, Alitalo K. Tammela T, et al. Among authors: tvorogov d. Nat Cell Biol. 2011 Sep 11;13(10):1202-13. doi: 10.1038/ncb2331. Nat Cell Biol. 2011. PMID: 21909098 Free PMC article.
38 results