Tyndale RF - Search Results

1

Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent.

Buchwald J, Chenoweth MJ, Palviainen T, Zhu G, Benner C, Gordon S, Korhonen T, Ripatti S, Madden PAF, Lehtimäki T, Raitakari OT, Salomaa V, Rose RJ, George TP, Lerman C, Pirinen M, Martin NG, Kaprio J, Loukola A, Tyndale RF. Buchwald J, et al. Among authors: tyndale rf. Mol Psychiatry. 2021 Jun;26(6):2212-2223. doi: 10.1038/s41380-020-0702-z. Epub 2020 Mar 10. Mol Psychiatry. 2021. PMID: 32157176 Free PMC article.

2

Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking.

Rao Y, Hoffmann E, Zia M, Bodin L, Zeman M, Sellers EM, Tyndale RF. Rao Y, et al. Among authors: tyndale rf. Mol Pharmacol. 2000 Oct;58(4):747-55. doi: 10.1124/mol.58.4.747. Mol Pharmacol. 2000. PMID: 10999944

3

A common genetic defect in nicotine metabolism decreases risk for dependence and lowers cigarette consumption.

Tyndale RF, Pianezza ML, Sellers EM. Tyndale RF, et al. Nicotine Tob Res. 1999;1 Suppl 2:S63-7; discussion S69-70. doi: 10.1080/14622299050011831. Nicotine Tob Res. 1999. PMID: 11768189 Review.

This paper outlines how genetic variation in the CYP2A6 gene may protect individuals from becoming nicotine-dependent smokers, and if dependent, how impairment of the CYP2A6 gene function decreases the number of cigarettes consumed by smokers (Pianezza M, Sellers EM, Tyndale …

This paper outlines how genetic variation in the CYP2A6 gene may protect individuals from becoming nicotine-dependent smokers, and if depend …

4

Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration.

Schoedel KA, Sellers EM, Palmour R, Tyndale RF. Schoedel KA, et al. Among authors: tyndale rf. Mol Pharmacol. 2003 Jan;63(1):96-104. doi: 10.1124/mol.63.1.96. Mol Pharmacol. 2003. PMID: 12488541

5

Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain.

Miksys S, Lerman C, Shields PG, Mash DC, Tyndale RF. Miksys S, et al. Among authors: tyndale rf. Neuropharmacology. 2003 Jul;45(1):122-32. doi: 10.1016/s0028-3908(03)00136-9. Neuropharmacology. 2003. PMID: 12814665

6

Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians.

Schoedel KA, Hoffmann EB, Rao Y, Sellers EM, Tyndale RF. Schoedel KA, et al. Among authors: tyndale rf. Pharmacogenetics. 2004 Sep;14(9):615-26. doi: 10.1097/00008571-200409000-00006. Pharmacogenetics. 2004. PMID: 15475735

7

Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy.

Malaiyandi V, Lerman C, Benowitz NL, Jepson C, Patterson F, Tyndale RF. Malaiyandi V, et al. Among authors: tyndale rf. Mol Psychiatry. 2006 Apr;11(4):400-9. doi: 10.1038/sj.mp.4001794. Mol Psychiatry. 2006. PMID: 16402128 Clinical Trial.

8

Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation.

Lerman C, Tyndale R, Patterson F, Wileyto EP, Shields PG, Pinto A, Benowitz N. Lerman C, et al. Clin Pharmacol Ther. 2006 Jun;79(6):600-8. doi: 10.1016/j.clpt.2006.02.006. Epub 2006 May 11. Clin Pharmacol Ther. 2006. PMID: 16765148 Clinical Trial.

9

Characterization and comparison of nicotine and cotinine metabolism in vitro and in vivo in DBA/2 and C57BL/6 mice.

Siu EC, Tyndale RF. Siu EC, et al. Among authors: tyndale rf. Mol Pharmacol. 2007 Mar;71(3):826-34. doi: 10.1124/mol.106.032086. Epub 2006 Dec 7. Mol Pharmacol. 2007. PMID: 17158199

10

Nicotine metabolism and CYP2A6 activity in a population of black African descent: impact of gender and light smoking.

Mwenifumbo JC, Sellers EM, Tyndale RF. Mwenifumbo JC, et al. Among authors: tyndale rf. Drug Alcohol Depend. 2007 Jun 15;89(1):24-33. doi: 10.1016/j.drugalcdep.2006.11.012. Epub 2006 Dec 8. Drug Alcohol Depend. 2007. PMID: 17161559

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