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Increased T cell proliferative responses to islet antigens identify clinical responders to anti-CD20 monoclonal antibody (rituximab) therapy in type 1 diabetes.
Herold KC, Pescovitz MD, McGee P, Krause-Steinrauf H, Spain LM, Bourcier K, Asare A, Liu Z, Lachin JM, Dosch HM; Type 1 Diabetes TrialNet Anti-CD20 Study Group. Herold KC, et al. J Immunol. 2011 Aug 15;187(4):1998-2005. doi: 10.4049/jimmunol.1100539. Epub 2011 Jul 20. J Immunol. 2011. PMID: 21775681 Free PMC article. Clinical Trial.
Rituximab, B-lymphocyte depletion, and preservation of beta-cell function.
Pescovitz MD, Greenbaum CJ, Krause-Steinrauf H, Becker DJ, Gitelman SE, Goland R, Gottlieb PA, Marks JB, McGee PF, Moran AM, Raskin P, Rodriguez H, Schatz DA, Wherrett D, Wilson DM, Lachin JM, Skyler JS; Type 1 Diabetes TrialNet Anti-CD20 Study Group. Pescovitz MD, et al. N Engl J Med. 2009 Nov 26;361(22):2143-52. doi: 10.1056/NEJMoa0904452. N Engl J Med. 2009. PMID: 19940299 Free PMC article. Clinical Trial.
Rituximab selectively suppresses specific islet antibodies.
Yu L, Herold K, Krause-Steinrauf H, McGee PL, Bundy B, Pugliese A, Krischer J, Eisenbarth GS; Type 1 Diabetes TrialNet Anti-CD20 Study Group. Yu L, et al. Diabetes. 2011 Oct;60(10):2560-5. doi: 10.2337/db11-0674. Epub 2011 Aug 10. Diabetes. 2011. PMID: 21831969 Free PMC article. Clinical Trial.
B-lymphocyte depletion with rituximab and β-cell function: two-year results.
Pescovitz MD, Greenbaum CJ, Bundy B, Becker DJ, Gitelman SE, Goland R, Gottlieb PA, Marks JB, Moran A, Raskin P, Rodriguez H, Schatz DA, Wherrett DK, Wilson DM, Krischer JP, Skyler JS; Type 1 Diabetes TrialNet Anti-CD20 Study Group. Pescovitz MD, et al. Diabetes Care. 2014 Feb;37(2):453-9. doi: 10.2337/dc13-0626. Epub 2013 Sep 11. Diabetes Care. 2014. PMID: 24026563 Free PMC article. Clinical Trial.