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407 results

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Page 1
Showing results for tsk g
Search for Tysk G instead (1 results)
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma.
Ji AL, Rubin AJ, Thrane K, Jiang S, Reynolds DL, Meyers RM, Guo MG, George BM, Mollbrink A, Bergenstråhle J, Larsson L, Bai Y, Zhu B, Bhaduri A, Meyers JM, Rovira-Clavé X, Hollmig ST, Aasi SZ, Nolan GP, Lundeberg J, Khavari PA. Ji AL, et al. Cell. 2020 Jul 23;182(2):497-514.e22. doi: 10.1016/j.cell.2020.05.039. Epub 2020 Jun 23. Cell. 2020. PMID: 32579974 Free PMC article.
To define the cellular composition and architecture of cutaneous squamous cell carcinoma (cSCC), we combined single-cell RNA sequencing with spatial transcriptomics and multiplexed ion beam imaging from a series of human cSCCs and matched normal skin. cSCC exhibited four tumor su …
To define the cellular composition and architecture of cutaneous squamous cell carcinoma (cSCC), we combined single-cell RNA sequencing with …
Hypocretin/Orexin Receptor Pharmacology and Sleep Phases.
Sun Y, Tisdale RK, Kilduff TS. Sun Y, et al. Front Neurol Neurosci. 2021;45:22-37. doi: 10.1159/000514963. Epub 2021 May 28. Front Neurol Neurosci. 2021. PMID: 34052813 Free PMC article. Review.
The hypocretins/orexins are two excitatory neuropeptides, alternately called HCRT1 or orexin-A and HCRT2 or orexin-B, that are the endogenous ligands for two G-protein-coupled receptors, HCRTR1/OX1R and HCRTR2/OX2R. Shortly after the discovery of this system, degeneration …
The hypocretins/orexins are two excitatory neuropeptides, alternately called HCRT1 or orexin-A and HCRT2 or orexin-B, that are the endogenou …
Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist.
Kawai T, Sun B, Yoshino H, Feng D, Suzuki Y, Fukazawa M, Nagao S, Wainscott DB, Showalter AD, Droz BA, Kobilka TS, Coghlan MP, Willard FS, Kawabe Y, Kobilka BK, Sloop KW. Kawai T, et al. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29959-29967. doi: 10.1073/pnas.2014879117. Epub 2020 Nov 11. Proc Natl Acad Sci U S A. 2020. PMID: 33177239 Free PMC article.
We report the discovery and mechanism of action of LY3502970 (OWL833), a nonpeptide GLP-1R agonist. LY3502970 is a partial agonist, biased toward G protein activation over beta-arrestin recruitment at the GLP-1R. The molecule is highly potent and selective against other cl …
We report the discovery and mechanism of action of LY3502970 (OWL833), a nonpeptide GLP-1R agonist. LY3502970 is a partial agonist, biased t …
Structural determinants of dual incretin receptor agonism by tirzepatide.
Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW. Sun B, et al. Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2116506119. doi: 10.1073/pnas.2116506119. Epub 2022 Mar 25. Proc Natl Acad Sci U S A. 2022. PMID: 35333651 Free PMC article.
Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits.
Langhans-Rajasekaran SA, Wan Y, Huang XY. Langhans-Rajasekaran SA, et al. Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8601-5. doi: 10.1073/pnas.92.19.8601. Proc Natl Acad Sci U S A. 1995. PMID: 7567982 Free PMC article.
The PH domain has been demonstrated to be able to interact with beta gamma subunits of heterotrimeric guanine nucleotide-binding proteins (G proteins) (G beta gamma) and phospholipids. Using cotransfection assays, we show here that the kinase activities of Tsk …
The PH domain has been demonstrated to be able to interact with beta gamma subunits of heterotrimeric guanine nucleotide-binding proteins ( …
Overcoming the Barrier.
Geha RM, Dhaliwal G, Winston LG, Kickler TS, Manesh R. Geha RM, et al. N Engl J Med. 2018 Dec 6;379(23):2256-2261. doi: 10.1056/NEJMcps1808494. N Engl J Med. 2018. PMID: 30575451 No abstract available.
Phytase.
Wodzinski RJ, Ullah AH. Wodzinski RJ, et al. Adv Appl Microbiol. 1996;42:263-302. doi: 10.1016/s0065-2164(08)70375-7. Adv Appl Microbiol. 1996. PMID: 8865587
The most conserved sequence is RHGXRXP. Phytase has been covalently immobilized on Fractogel TSK HW-75 F and glutaraldehyde-activated silicate. It has been immobilized on agarose. ...The bioengineered organism produces 270 microns P/ml/min (4500 nKat/ml) which is approxima …
The most conserved sequence is RHGXRXP. Phytase has been covalently immobilized on Fractogel TSK HW-75 F and glutaraldehyde-activated …
Stopping Aspirin Within 1 Month After Stenting for Ticagrelor Monotherapy in Acute Coronary Syndrome: The T-PASS Randomized Noninferiority Trial.
Hong SJ, Lee SJ, Suh Y, Yun KH, Kang TS, Shin S, Kwon SW, Lee JW, Cho DK, Park JK, Bae JW, Kang WC, Kim S, Lee YJ, Ahn CM, Kim JS, Kim BK, Ko YG, Choi D, Jang Y, Hong MK; T-PASS (Ticagrelor Monotherapy in Patients Treated With New-Generation Drug-Eluting Stents for Acute Coronary Syndrome) Investigators. Hong SJ, et al. Circulation. 2024 Feb 20;149(8):562-573. doi: 10.1161/CIRCULATIONAHA.123.066943. Epub 2023 Oct 25. Circulation. 2024. PMID: 37878786 Clinical Trial.
Ischemic Preconditioning and Muscle Force Capabilities.
Valenzuela PL, Martín-Candilejo R, Sánchez-Martínez G, Bouzas Marins JC, de la Villa P, Sillero-Quintana M. Valenzuela PL, et al. J Strength Cond Res. 2021 Aug 1;35(8):2187-2192. doi: 10.1519/JSC.0000000000003104. J Strength Cond Res. 2021. PMID: 30908369 Clinical Trial.
Valenzuela, PL, Martin-Candilejo, R, Sanchez-Martinez, G, Bouzas Marins, JC, de la Villa, P, and Sillero-Quintana, M. ...However, exercise resulted in a similar Tsk increase in the pectoral muscles in both conditions (p > 0.05). ...
Valenzuela, PL, Martin-Candilejo, R, Sanchez-Martinez, G, Bouzas Marins, JC, de la Villa, P, and Sillero-Quintana, M. ...However, exe …
407 results