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Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.
Nat Commun. 2019 Jan 15;10(1):224. doi: 10.1038/s41467-018-08115-8.
Nat Commun. 2019.
PMID: 30644389
Free PMC article.
NRAS Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS-MAPK Pathway in Neuroblastoma.
Valencia-Sama I, Ladumor Y, Kee L, Adderley T, Christopher G, Robinson CM, Kano Y, Ohh M, Irwin MS.
Valencia-Sama I, et al.
Cancer Res. 2020 Aug 15;80(16):3413-3423. doi: 10.1158/0008-5472.CAN-19-3822. Epub 2020 Jun 25.
Cancer Res. 2020.
PMID: 32586982
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The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors.
Gebregiworgis T, Kano Y, St-Germain J, Radulovich N, Udaskin ML, Mentes A, Huang R, Poon BPK, He W, Valencia-Sama I, Robinson CM, Huestis M, Miao J, Yeh JJ, Zhang ZY, Irwin MS, Lee JE, Tsao MS, Raught B, Marshall CB, Ohh M, Ikura M.
Gebregiworgis T, et al. Among authors: valencia sama i.
Nat Commun. 2021 Nov 1;12(1):6274. doi: 10.1038/s41467-021-26526-y.
Nat Commun. 2021.
PMID: 34725361
Free PMC article.
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Vitamin D Receptor Activation Attenuates Hippo Pathway Effectors and Cell Survival in Metastatic Neuroblastoma.
Ladumor Y, Seong BKA, Hallett R, Valencia-Sama I, Adderley T, Wang Y, Kee L, Gont A, Kaplan DR, Irwin MS.
Ladumor Y, et al. Among authors: valencia sama i.
Mol Cancer Res. 2022 Jun 3;20(6):895-908. doi: 10.1158/1541-7786.MCR-21-0425.
Mol Cancer Res. 2022.
PMID: 35190818
Free PMC article.
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Combination mTOR and SHP2 inhibitor treatment of lymphatic malformation endothelial cells.
Wolter JK, Valencia-Sama I, Osborn AJ, Propst EJ, Irwin MS, Papsin B, Wolter NE.
Wolter JK, et al. Among authors: valencia sama i.
Microvasc Res. 2022 Sep;143:104397. doi: 10.1016/j.mvr.2022.104397. Epub 2022 Jun 6.
Microvasc Res. 2022.
PMID: 35671835
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SHP2 Inhibition with TNO155 Increases Efficacy and Overcomes Resistance of ALK Inhibitors in Neuroblastoma.
Valencia-Sama I, Kee L, Christopher G, Ohh M, Layeghifard M, Shlien A, Hayes MN, Irwin MS.
Valencia-Sama I, et al.
Cancer Res Commun. 2023 Dec 27;3(12):2608-2622. doi: 10.1158/2767-9764.CRC-23-0234.
Cancer Res Commun. 2023.
PMID: 38032104
Free PMC article.
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Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor.
Valencia-Sama I, Zhao Y, Lai D, Janse van Rensburg HJ, Hao Y, Yang X.
Valencia-Sama I, et al.
J Biol Chem. 2015 Jul 3;290(27):16906-17. doi: 10.1074/jbc.M115.642363. Epub 2015 May 20.
J Biol Chem. 2015.
PMID: 25995450
Free PMC article.
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