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Metopimazine is primarily metabolized by a liver amidase in humans.
Busby RW, Cai X, Yang S, Ramos L, Venkatarangan L, Shen H, Wax S, Sadeque AJM, De Colle C. Busby RW, et al. Among authors: venkatarangan l. Pharmacol Res Perspect. 2022 Feb;10(1):e00903. doi: 10.1002/prp2.903. Pharmacol Res Perspect. 2022. PMID: 34918875 Free PMC article. Clinical Trial.
LC-MS/MS bioanalysis of plasma 1, 14-tetradecanedioic acid and 1, 16-hexadecanedioic acid as candidate biomarkers for organic anion-transporting polypeptide mediated drug-drug interactions.
Santockyte R, Kandoussi H, Chen W, Zheng N, Venkatarangan L, Gan J, Shen H, Bonacorsi SJ, Easter J, Burrell R, Zhang YJ, Zeng J. Santockyte R, et al. Among authors: venkatarangan l. Bioanalysis. 2018 Sep 1;10(18):1473-1485. doi: 10.4155/bio-2018-0170. Epub 2018 Sep 14. Bioanalysis. 2018. PMID: 30215261