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EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis.
Tonna S, Takyar FM, Vrahnas C, Crimeen-Irwin B, Ho PW, Poulton IJ, Brennan HJ, McGregor NE, Allan EH, Nguyen H, Forwood MR, Tatarczuch L, Mackie EJ, Martin TJ, Sims NA. Tonna S, et al. Among authors: vrahnas c. FASEB J. 2014 Oct;28(10):4482-96. doi: 10.1096/fj.14-254300. Epub 2014 Jun 30. FASEB J. 2014. PMID: 24982128
RARγ is a negative regulator of osteoclastogenesis.
Green AC, Poulton IJ, Vrahnas C, Häusler KD, Walkley CR, Wu JY, Martin TJ, Gillespie MT, Chandraratna RA, Quinn JM, Sims NA, Purton LE. Green AC, et al. Among authors: vrahnas c. J Steroid Biochem Mol Biol. 2015 Jun;150:46-53. doi: 10.1016/j.jsbmb.2015.03.005. Epub 2015 Mar 20. J Steroid Biochem Mol Biol. 2015. PMID: 25800721
Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone.
Vrahnas C, Blank M, Dite TA, Tatarczuch L, Ansari N, Crimeen-Irwin B, Nguyen H, Forwood MR, Hu Y, Ikegame M, Bambery KR, Petibois C, Mackie EJ, Tobin MJ, Smyth GK, Oakhill JS, Martin TJ, Sims NA. Vrahnas C, et al. Nat Commun. 2019 Jul 31;10(1):3436. doi: 10.1038/s41467-019-11373-9. Nat Commun. 2019. PMID: 31366886 Free PMC article.
Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly.
Kinross KM, Montgomery KG, Mangiafico SP, Hare LM, Kleinschmidt M, Bywater MJ, Poulton IJ, Vrahnas C, Henneicke H, Malaterre J, Waring PM, Cullinane C, Sims NA, McArthur GA, Andrikopoulos S, Phillips WA. Kinross KM, et al. Among authors: vrahnas c. FASEB J. 2015 Apr;29(4):1426-34. doi: 10.1096/fj.14-262782. Epub 2014 Dec 30. FASEB J. 2015. PMID: 25550458
Author Correction: Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone.
Vrahnas C, Blank M, Dite TA, Tatarczuch L, Ansari N, Crimeen-Irwin B, Nguyen H, Forwood MR, Hu Y, Ikegame M, Bambery KR, Petibois C, Mackie EJ, Tobin MJ, Smyth GK, Oakhill JS, Martin TJ, Sims NA. Vrahnas C, et al. Nat Commun. 2019 Nov 4;10(1):5073. doi: 10.1038/s41467-019-13040-5. Nat Commun. 2019. PMID: 31685818 Free PMC article.
13 results