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Functional assays for classification of BRCA2 variants of uncertain significance.
Farrugia DJ, Agarwal MK, Pankratz VS, Deffenbaugh AM, Pruss D, Frye C, Wadum L, Johnson K, Mentlick J, Tavtigian SV, Goldgar DE, Couch FJ. Farrugia DJ, et al. Among authors: wadum l. Cancer Res. 2008 May 1;68(9):3523-31. doi: 10.1158/0008-5472.CAN-07-1587. Cancer Res. 2008. PMID: 18451181 Free PMC article.
Pooled analysis indicates that the GSTT1 deletion, GSTM1 deletion, and GSTP1 Ile105Val polymorphisms do not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers.
Spurdle AB, Fahey P, Chen X, McGuffog L; kConFab; Easton D, Peock S, Cook M; EMBRACE; Simard J; INHERIT; Rebbeck TR; MAGIC; Antoniou AC, Chenevix-Trench G. Spurdle AB, et al. Breast Cancer Res Treat. 2010 Jul;122(1):281-5. doi: 10.1007/s10549-009-0601-0. Epub 2009 Nov 18. Breast Cancer Res Treat. 2010. PMID: 19921428 Free PMC article.
TBX2 is preferentially amplified in BRCA1- and BRCA2-related breast tumors.
Sinclair CS, Adem C, Naderi A, Soderberg CL, Johnson M, Wu K, Wadum L, Couch VL, Sellers TA, Schaid D, Slezak J, Fredericksen Z, Ingle JN, Hartmann L, Jenkins RB, Couch FJ. Sinclair CS, et al. Among authors: wadum l. Cancer Res. 2002 Jul 1;62(13):3587-91. Cancer Res. 2002. PMID: 12097257