Warfel NA - Search Results

1

Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling.

Warfel NA, Newton AC. Warfel NA, et al. J Biol Chem. 2012 Feb 3;287(6):3610-6. doi: 10.1074/jbc.R111.318675. Epub 2011 Dec 5. J Biol Chem. 2012. PMID: 22144674 Free PMC article.

2

Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms.

Gills JJ, Castillo SS, Zhang C, Petukhov PA, Memmott RM, Hollingshead M, Warfel N, Han J, Kozikowski AP, Dennis PA. Gills JJ, et al. J Biol Chem. 2007 Sep 14;282(37):27020-27029. doi: 10.1074/jbc.M701108200. Epub 2007 Jul 13. J Biol Chem. 2007. PMID: 17631503 Free article.

3

Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C.

Brognard J, Niederst M, Reyes G, Warfel N, Newton AC. Brognard J, et al. J Biol Chem. 2009 May 29;284(22):15215-23. doi: 10.1074/jbc.M901468200. Epub 2009 Mar 26. J Biol Chem. 2009. PMID: 19324870 Free PMC article.

4

Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.

Warfel NA, Niederst M, Stevens MW, Brennan PM, Frame MC, Newton AC. Warfel NA, et al. J Biol Chem. 2011 Jun 3;286(22):19777-88. doi: 10.1074/jbc.M111.237081. Epub 2011 Mar 28. J Biol Chem. 2011. PMID: 21454620 Free PMC article.

5

Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2.

Warfel NA, Niederst M, Newton AC. Warfel NA, et al. J Biol Chem. 2011 Nov 11;286(45):39122-9. doi: 10.1074/jbc.M111.278747. Epub 2011 Sep 9. J Biol Chem. 2011. PMID: 21908613 Free PMC article.

6

HIF-1 signaling in drug resistance to chemotherapy.

Warfel NA, El-Deiry WS. Warfel NA, et al. Curr Med Chem. 2014;21(26):3021-8. doi: 10.2174/0929867321666140414101056. Curr Med Chem. 2014. PMID: 24735366 Review.

7

Importance of the stress kinase p38alpha in mediating the direct cytotoxic effects of the thalidomide analogue, CPS49, in cancer cells and endothelial cells.

Warfel NA, Lepper ER, Zhang C, Figg WD, Dennis PA. Warfel NA, et al. Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3502-9. doi: 10.1158/1078-0432.CCR-05-1837. Clin Cancer Res. 2006. PMID: 16740776

8

Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors.

Granville CA, Warfel N, Tsurutani J, Hollander MC, Robertson M, Fox SD, Veenstra TD, Issaq HJ, Linnoila RI, Dennis PA. Granville CA, et al. Clin Cancer Res. 2007 Apr 1;13(7):2281-9. doi: 10.1158/1078-0432.CCR-06-2570. Clin Cancer Res. 2007. PMID: 17404113

9

Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo.

Gills JJ, Lopiccolo J, Tsurutani J, Shoemaker RH, Best CJ, Abu-Asab MS, Borojerdi J, Warfel NA, Gardner ER, Danish M, Hollander MC, Kawabata S, Tsokos M, Figg WD, Steeg PS, Dennis PA. Gills JJ, et al. Among authors: warfel na. Clin Cancer Res. 2007 Sep 1;13(17):5183-94. doi: 10.1158/1078-0432.CCR-07-0161. Clin Cancer Res. 2007. PMID: 17785575

10

PIM kinase (and Akt) biology and signaling in tumors.

Warfel NA, Kraft AS. Warfel NA, et al. Pharmacol Ther. 2015 Jul;151:41-9. doi: 10.1016/j.pharmthera.2015.03.001. Epub 2015 Mar 5. Pharmacol Ther. 2015. PMID: 25749412 Free PMC article. Review.

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