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Pharmacologic profiles of investigational kisspeptin/metastin analogues, TAK-448 and TAK-683, in adult male rats in comparison to the GnRH analogue leuprolide.
Matsui H, Masaki T, Akinaga Y, Kiba A, Takatsu Y, Nakata D, Tanaka A, Ban J, Matsumoto S, Kumano S, Suzuki A, Ikeda Y, Yamaguchi M, Watanabe T, Ohtaki T, Kusaka M. Matsui H, et al. Among authors: watanabe t. Eur J Pharmacol. 2014 Jul 15;735:77-85. doi: 10.1016/j.ejphar.2014.03.058. Epub 2014 Apr 18. Eur J Pharmacol. 2014. PMID: 24747751
Suppression of the hypothalamic-pituitary-gonadal axis by TAK-385 (relugolix), a novel, investigational, orally active, small molecule gonadotropin-releasing hormone (GnRH) antagonist: studies in human GnRH receptor knock-in mice.
Nakata D, Masaki T, Tanaka A, Yoshimatsu M, Akinaga Y, Asada M, Sasada R, Takeyama M, Miwa K, Watanabe T, Kusaka M. Nakata D, et al. Among authors: watanabe t. Eur J Pharmacol. 2014 Jan 15;723:167-74. doi: 10.1016/j.ejphar.2013.12.001. Epub 2013 Dec 11. Eur J Pharmacol. 2014. PMID: 24333551
An administration of TAK-683 at a minimally effective dose for luteinizing hormone stimulation under the absence of the ovary induces luteinizing hormone surge in ovary-intact goats.
Kanai N, Endo N, Ohkura S, Wakabayashi Y, Matsui H, Matsumoto H, Ishikawa K, Tanaka A, Watanabe T, Okamura H, Tanaka T. Kanai N, et al. Among authors: watanabe t. J Reprod Dev. 2017 Jun 21;63(3):305-310. doi: 10.1262/jrd.2016-184. Epub 2017 Mar 24. J Reprod Dev. 2017. PMID: 28344194 Free PMC article.
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